A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications.
A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications.
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DOI：
10.1002/ame2.12340
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发表时间：
2023-10
影响因子：
3.7
通讯作者：
Brankov, Jovan G.
中科院分区：
文献类型：
--
作者：
Rounds, Cody C.;Li, Chengyue;Zhou, Wei;Tichauer, Kenneth M.;Brankov, Jovan G.
关键词：
随着乳腺X射线成像技术的进步和软组织对比度的提高，系统设计和组件校准需要可靠的成像体模。在先进的成像模式中，如基于折射的方法，至关重要的是，开发的体模捕获临床癌前和癌性病例中看到的生物细节，同时最大限度地减少可能由于体模产生而导致的伪影。这项工作提出了一个乳房组织成像体模的尸体乳房组织适用于传输和折射增强成像系统的制造。人癌细胞肿瘤在裸无胸腺小鼠中原位生长，并植入固定的组织中，同时保持天然肿瘤/脂肪组织界面。将得到的人-鼠组织混合体模安装在透明丙烯酸外壳上，用于吸收和折射X射线成像。还进行了数字乳腺断层合成摄影。提供了体模的基于衰减的成像和基于折射的成像，以确认该体模在两种成像模式中使用的适用性。这项工作提出了一个乳房组织成像体模的尸体乳房组织适合传输以及折射增强成像系统的制造。原位肿瘤在裸无胸腺小鼠中生长，随后植入固定的组织中，同时保持天然肿瘤/脂肪组织界面。体模安装在丙烯酸外壳中，用于吸收和折射X射线成像。在视网膜节段可见明显的病变。以及吸收图像（A，B），并且如基于折射的图像（C）中所见，折射率失配在注入边界处被最小化。
As mammography X‐ray imaging technologies advance and provide elevated contrast in soft tissues, a need has developed for reliable imaging phantoms for use in system design and component calibration. In advanced imaging modalities such as refraction‐based methods, it is critical that developed phantoms capture the biological details seen in clinical precancerous and cancerous cases while minimizing artifacts that may be caused due to phantom production. This work presents the fabrication of a breast tissue imaging phantom from cadaveric breast tissue suitable for use in both transmission and refraction‐enhanced imaging systems. Human cancer cell tumors were grown orthotopically in nude athymic mice and implanted into the fixed tissue while maintaining the native tumor/adipose tissue interface. The resulting human–murine tissue hybrid phantom was mounted on a clear acrylic housing for absorption and refraction X‐ray imaging. Digital breast tomosynthesis was also performed. Both attenuation‐based imaging and refraction‐based imaging of the phantom are presented to confirm the suitability of this phantom's use in both imaging modalities. This work presents the fabrication of a breast tissue imaging phantom from cadaveric breast tissue suitable for both transmission as well as refraction‐enhanced imaging systems. Orthotopic tumors were grown in nude athymic mice, followed by implantation into fixed tissue while maintaining the native tumor/adipose tissue interface. The phantom is mounted in an acrylic housing for absorption and refraction x‐ray imaging. Clearly defined lesions are seen in the R.G.B. as well as absorption images (A, B), and refractive index mismatch is minimized at the implantation boundary as seen in the refraction‐based image (C).
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影响因子：
1.6
作者：
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通讯作者：
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