Extensive diversity of coronaviruses in bats from China.
Extensive diversity of coronaviruses in bats from China.
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DOI：
10.1016/j.virol.2017.03.019
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发表时间：
2017-07
期刊：
影响因子：
3.7
通讯作者：
Zhang YZ
中科院分区：
文献类型：
--
作者：
Lin XD;Wang W;Hao ZY;Wang ZX;Guo WP;Guan XQ;Wang MR;Wang HW;Zhou RH;Li MH;Tang GP;Wu J;Holmes EC;Zhang YZ
为了帮助揭示蝙蝠冠状病毒的多样性和进化，我们收集了来自中国21个物种的1067只蝙蝠。在这些蝙蝠中共鉴定出73种冠状病毒（32种冠状病毒和41种β冠状病毒），总体患病率为6.84%。所有新发现的β冠状病毒均为SARS相关菊头蝠冠状病毒（SARSr-Rh-BatCoV）。重要的是，除S基因外，贵州省SARS-Rh-BatCoV的基因组序列与SARS相关的人类冠状病毒密切相关。此外，新发现的冠状病毒表现出高度的遗传多样性，有些可能代表新物种。我们的系统发育分析还提供了深入了解这些病毒在蝙蝠物种之间的传播，揭示了地理位置，而不是蝙蝠物种的一般聚类。同一属的蝙蝠之间的种间传播也是常见的两种冠状病毒和β冠状病毒。总的来说，这些数据表明，特定蝙蝠物种之间的高接触率使冠状病毒能够获得和传播。在中国蝙蝠样本中鉴定出32种α-CoV和41种β-CoV。贵州省SARS-Rh-BatCoV与SARS-CoV亲缘关系较近。一些新发现的冠状病毒可能是α冠状病毒属的新物种。一些蝙蝠物种之间的高接触率使冠状病毒的获得和传播成为可能。
To help reveal the diversity and evolution of bat coronaviruses we collected 1067 bats from 21 species in China. A total of 73 coronaviruses (32 alphacoronaviruses and 41 betacoronaviruses) were identified in these bats, with an overall prevalence of 6.84%. All newly-identified betacoronaviruses were SARS-related Rhinolophus bat coronaviruses (SARSr-Rh-BatCoV). Importantly, with the exception of the S gene, the genome sequences of the SARSr-Rh-BatCoVs sampled in Guizhou province were closely related to SARS-related human coronavirus. Additionally, the newly-identified alphacoronaviruses exhibited high genetic diversity and some may represent novel species. Our phylogenetic analyses also provided insights into the transmission of these viruses among bat species, revealing a general clustering by geographic location rather than by bat species. Inter-species transmission among bats from the same genus was also commonplace in both the alphacoronaviruses and betacoronaviruses. Overall, these data suggest that high contact rates among specific bat species enable the acquisition and spread of coronaviruses. 32 alpha-CoVs and 41 beta-CoVs were identified in bats sampled from China. SARSr-Rh-BatCoVs from Guizhou province were closely related to SARS-CoV. Some of the newly identified CoVs may be novel species in the genus Alphacoronavirus. High contact rates among some bat species enable the acquisition and spread of CoVs.
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