Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents.
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蝙蝠、食虫动物和啮齿动物携带的汉坦病毒的系统发育和起源
DOI：
10.1371/journal.ppat.1003159
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发表时间：
2013-02
期刊：
影响因子：
6.7
通讯作者：
Zhang YZ
中科院分区：
文献类型：
--
作者：
Guo WP;Lin XD;Wang W;Tian JH;Cong ML;Zhang HL;Wang MR;Zhou RH;Wang JB;Li MH;Xu J;Holmes EC;Zhang YZ
汉坦病毒是人类最重要的人畜共患病原体之一，也是全球高度关注的主题。尽管汉坦病毒对公共卫生的重要性，但对其进化史，特别是病毒-宿主共趋异与跨种属病毒传播的频率没有达成共识。记录汉坦病毒生物多样性的程度，特别是它们的哺乳动物宿主范围，对解决这一问题至关重要。在此，我们描述了从中国蝙蝠和鼩 鼱中采集的四种新的汉坦病毒（黄陂病毒、两河病毒、龙泉病毒和牙克石病毒），它们与其他已知的汉坦病毒不同。黄皮病毒见于伏翼，梁河病毒见于短尾鼩，龙泉病毒见于菊头蝠、中华菊头蝠和独角菊头蝠，牙克石病毒见于等齿鼩。汉坦病毒的可用多样性的系统发育分析揭示了存在四个感染一系列哺乳动物宿主的hantaviruses组，以及hantaviruses组之间古老的重配事件的发生。值得注意的是，病毒的系统发育史并不总是与其宿主一致，这表明跨物种传播在汉坦病毒进化过程中发挥了重要作用，并在所有分类水平，虽然我们也注意到一些证据，病毒宿主共趋异。我们的系统发育分析还表明，汉坦病毒可能首先出现在翼手目（蝙蝠）或Soricomorpha（鼹鼠和鼩），然后才出现在啮齿动物物种。总体而言，这些数据表明蝙蝠可能是汉坦病毒的重要天然储存宿主。
Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-species virus transmission. Documenting the extent of hantavirus biodiversity, and particularly their range of mammalian hosts, is critical to resolving this issue. Here, we describe four novel hantaviruses (Huangpi virus, Lianghe virus, Longquan virus, and Yakeshi virus) sampled from bats and shrews in China, and which are distinct from other known hantaviruses. Huangpi virus was found in Pipistrellus abramus, Lianghe virus in Anourosorex squamipes, Longquan virus in Rhinolophus affinis, Rhinolophus sinicus, and Rhinolophus monoceros, and Yakeshi virus in Sorex isodon, respectively. A phylogenetic analysis of the available diversity of hantaviruses reveals the existence of four phylogroups that infect a range of mammalian hosts, as well as the occurrence of ancient reassortment events between the phylogroups. Notably, the phylogenetic histories of the viruses are not always congruent with those of their hosts, suggesting that cross-species transmission has played a major role during hantavirus evolution and at all taxonomic levels, although we also noted some evidence for virus-host co-divergence. Our phylogenetic analysis also suggests that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Overall, these data indicate that bats are likely to be important natural reservoir hosts of hantaviruses.
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影响因子：
5.4
作者：
Kang, Hae Ji;Bennett, Shannon N.;Yanagihara, Richard
通讯作者：
Yanagihara, Richard
DOI：
10.4269/ajtmh.2011.11-0034
发表时间：
2011-09-01
影响因子：
3.3
作者：
Kang, Hae Ji;Kosoy, Michael Y.;Yanagihara, Richard
通讯作者：
Yanagihara, Richard
影响因子：
2.1
作者：
Kang, Hae Ji;Arai, Satoru;Yanagihara, Richard
通讯作者：
Yanagihara, Richard
影响因子：
10.7
作者：
Hughes, AL;Friedman, R
通讯作者：
Friedman, R
影响因子：
1.7
作者：
Li, Gang;Jones, Gareth;Zhang, Shuyi
通讯作者：
Zhang, Shuyi