Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes.

Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes.
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通过整合到脂质体膜中的富勒烯/捕光天线分子组装系统的光动力活性消除细菌。

DOI:
10.1039/d0na00132e
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发表时间:
2020-10-13
期刊:
影响因子:
4.7
通讯作者:
--
中科院分区:
材料科学3区
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--
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传播的容易性和极高的死亡率使基于病原体的感染成为一个持续的全球威胁。在本文中,描述了一种容易的细菌消除过程,其基于由整合到脂质体膜中的捕光天线分子组成的富勒烯的光动力活性。这样做是为了扩大富勒烯衍生物的吸收能力。从光活化的天线分子到富勒烯的有效能量转移增强了抗微生物活性,即使在照射下也没有对红细胞的任何有害的裂解活性。通过从富勒烯衍生物经由光活化的捕光天线分子的有效能量转移产生的单线态氧(1O2)来实现细菌消除。
Ease of transmission and exceptionally high mortality rates make pathogen-based infections an ongoing global threat. Herein, a facile bacterial elimination process is described which is based on the photodynamic activity of fullerenes composed of light-harvesting antenna molecules integrated into liposome membranes. This was done to expand the absorption capabilities of fullerene derivatives. Efficient energy transfer from the photoactivated antenna molecules to the fullerenes enhanced antimicrobial activity without any harmful lytic activity against red blood cells even under irradiation. Bacterial elimination was attained by singlet oxygen (1O2) generated from fullerene derivatives via efficient energy transfer from photo-activated light-harvesting antenna molecules.
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