The endoplasmic reticulum in plant immunity and cell death.
The endoplasmic reticulum in plant immunity and cell death.
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DOI：
10.3389/fpls.2012.00200
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发表时间：
2012
影响因子：
5.6
通讯作者：
Schäfer P
中科院分区：
文献类型：
--
作者：
Eichmann R;Schäfer P
内质网（ER）是真核细胞中一个高度动态的细胞器，也是植物液泡、质膜或质外体蛋白质的主要生产场所。在ER，这些分泌的蛋白质经历多个处理步骤，这些步骤由ER质量控制系统监督和进行。值得注意的是，分泌蛋白的加工在应激条件下可以显著提高并超过ER折叠能力。由此产生的未折叠蛋白质的积累被定义为ER应激。细胞重建适当ER功能的效率对于压力适应至关重要。除了提供蛋白质直接对抗和解决应激条件，ER监测免疫受体的合成。这表明ER对植物免疫系统的建立和功能的重要性。最近的研究指出了整个系统的脆弱性，并强调ER作为植物中程序性细胞死亡（PCD）的启动子，如脊椎动物所报道的那样。本文综述了ER对免疫和PCD信号传导的影响。了解内质网对逆境信号的整合，对于优化植物的发育和提高植物的抗逆性具有重要的意义。
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants. At the ER, these secreted proteins undergo multiple processing steps, which are supervised and conducted by the ER quality control system. Notably, processing of secreted proteins can considerably elevate under stress conditions and exceed ER folding capacities. The resulting accumulation of unfolded proteins is defined as ER stress. The efficiency of cells to re-establish proper ER function is crucial for stress adaptation. Besides delivering proteins directly antagonizing and resolving stress conditions, the ER monitors synthesis of immune receptors. This indicates the significance of the ER for the establishment and function of the plant immune system. Recent studies point out the fragility of the entire system and highlight the ER as initiator of programed cell death (PCD) in plants as was reported for vertebrates. This review summarizes current knowledge on the impact of the ER on immune and PCD signaling. Understanding the integration of stress signals by the ER bears a considerable potential to optimize development and to enhance stress resistance of plants.
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影响因子：
11.6
作者：
Jelitto-Van Dooren, EPWM;Vidal, S;Denecke, J
通讯作者：
Denecke, J
DOI：
10.1073/pnas.0408941102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Iwata, Y;Koizumi, N
通讯作者：
Koizumi, N
影响因子：
16
作者：
Harding, HP;Novoa, I;Ron, D
通讯作者：
Ron, D
影响因子：
5.6
作者：
Hüttner S;Strasser R
通讯作者：
Strasser R
影响因子：
7.3
作者：
Che, Ping;Bussell, John D.;Smith, Steven M.
通讯作者：
Smith, Steven M.