An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair.
An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center: a staging system in need of repair.
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DOI：
10.1002/cncr.27727
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发表时间：
2013-01-01
期刊：
影响因子：
6.2
通讯作者：
Sturgis, Erich M.
中科院分区：
文献类型：
--
作者：
Dahlstrom, Kristina R.;Calzada, Gabriel;Hanby, Jennifer D.;Garden, Adam S.;Glisson, Bonnie S.;Li, Guojun;Roberts, Dianna B.;Weber, Randal S.;Sturgis, Erich M.
关键词：
本回顾性综述检查了三级癌症中心口咽鳞状细胞癌 (SCCOP) 患者的人口统计学/临床特征和总体生存率，并报告了随着时间的推移影响任何观察到的生存趋势的特征。该研究纳入了 1955 年至 2004 年间就诊于我们机构的 3891 名新诊断、既往未接受治疗的患者。随着时间的推移，患者就诊的年龄越来越小，更有可能患有舌根或扁桃体肿瘤，并且从未吸烟或以前吸烟过。 1995-2004 年诊断的患者死亡可能性几乎是 1995 年之前诊断的患者的一半（HR，0.6；95% CI，0.6-0.8）。在多变量和递归分区生存分析中，TNM 分期系统预测了 1995 年之前接受治疗的患者的生存，但没有预测 1995-2004 年接受治疗的患者的生存。过去 50 年来，SCCOP 患者的生存率显着提高。主要影响因素是临床特征的变化，特别是 HPV 阳性替代指标的变化。目前 SCCOP 的 TNM 分期系统不够充分。鼓励纳入 HPV 状况以及吸烟状况。
This retrospective review examines demographic/clinical characteristics and overall survival of patients with squamous cell carcinoma of the oropharynx (SCCOP) at a tertiary cancer center and reports the characteristics influencing any observed survival trends over time. The study included 3891 newly diagnosed, previously untreated patients presenting to our institution between 1955 and 2004. Over time, patients presented at younger ages and were more likely to have base of tongue or tonsil tumors and to be never or former smokers. Patients diagnosed in 1995–2004 were almost half as likely to die as those diagnosed before 1995 (HR,0.6; 95% CI,0.6–0.8). In both multivariable and recursive partitioning survival analyses, the TNM staging system predicted survival of patients treated before 1995 but not of patients treated in 1995–2004. Survival among patients with SCCOP improved substantially over the past 50 years. The main contributing factors were changes in clinical characteristics, in particular surrogates for HPV positivity. The current TNM staging system for SCCOP is inadequate. Incorporation of HPV status and perhaps smoking status is encouraged.
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影响因子：
6.2
作者：
Shiboski, CH;Schmidt, BL;Jordan, RCK
通讯作者：
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影响因子：
6.4
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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影响因子：
10.3
作者：
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通讯作者：
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