Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.
Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.
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进化和表达分析显示 khdrbs 基因共同选择脊椎动物大脑的起源
DOI：
10.3389/fgene.2017.00225
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发表时间：
2017
影响因子：
3.7
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Wang S;Yang Q;Wang Z;Feng S;Li H;Ji D;Zhang S
由全基因组复制（WGD）产生的基因可以通过改变其调控过程或改变其编码蛋白而被增选，这已被证明有助于脊椎动物形态新奇的出现，如脊椎动物软骨。与无脊椎动物不同，小鼠的khdrbs基因主要在大脑中表达，提示khdrbs基因家族作为遗传工具箱的成员可能与脊椎动物的大脑发育有关。然而，khdrbs基因家族与脊椎动物脑发育的进化关系尚不清楚。首先，我们分析了后生动物khdrbs基因家族的进化历史，然后研究了它们在斑马鱼早期发育和成年期的表达模式。我们发现斑马鱼在WGD作用下发生了khdrbs基因家族的重复，并且所有的khdrbs基因在发育早期主要在脑亚结构中表达。鉴于无脊椎动物khdrbs基因在种系中的表达，斑马鱼khdrbs基因在脑中的不同表达域表明，重复的khdrbs基因被增选促进了脊椎动物脑的进化起源。
Genes generated by whole genome duplications (WGD) can be co-opted by changing their regulation process or altering their coding proteins, which has been shown contributable to the emergence of vertebrate morphological novelties such as vertebrate cartilage. Mouse khdrbs genes, differing from its invertebrate orthologs, were mainly expressed in brain, hinting that khdrbs gene family as a member of genetic toolkit may be linked to vertebrate brain development. However, the evolutionary relationship between khdrbs gene family and vertebrate brain development is unclear. First, we analyzed the evolutionary history of khdrbs gene family in metazoans, and then investigated their expression patterns during early development and in adulthood of zebrafish. We found that the duplication of khdrbs gene family by WGD took place in zebrafish, and all zebrafish khdrbs genes were predominantly expressed in the substructures of brain during early development. Given the expression of invertebrate khdrbs gene in germ line, the distinct expression domains of zebrafish khdrbs genes in brain suggested that the duplicated khdrbs genes are co-opted for promoting the evolutionary origin of vertebrate brain.
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影响因子：
4.5
作者：
Ding Y;Zhao L;Yang S;Jiang Y;Chen Y;Zhao R;Zhang Y;Zhang G;Dong Y;Yu H;Zhou Q;Wang W
通讯作者：
Wang W
影响因子：
4.6
作者：
Hensley MR;Cui Z;Chua RF;Simpson S;Shammas NL;Yang JY;Leung YF;Zhang G
通讯作者：
Zhang G
影响因子：
10.7
作者：
Fan, Chuanzhu;Chen, Ying;Long, Manyuan
通讯作者：
Long, Manyuan
DOI：
10.1073/pnas.96.6.2710
发表时间：
1999-03-16
影响因子：
11.1
作者：
Di Fruscio, M;Chen, TP;Richard, S
通讯作者：
Richard, S
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF