In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.
In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.
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DOI：
10.1038/srep00642
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发表时间：
2012
影响因子：
4.6
通讯作者：
Sugai, Manabu
中科院分区：
文献类型：
--
作者：
Nambu, Yukiko;Hayashi, Tatsunari;Jang, Kyoung-Jin;Aoki, Koji;Mano, Hiroto;Nakano, Keiko;Osato, Motomi;Takahashi, Katsu;Itoh, Katsuhiko;Teramukai, Satoshi;Komori, Toshihisa;Fujita, Jun;Ito, Yoshiaki;Shimizu, Akira;Sugai, Manabu
在胸腺中，CD 4辅助T细胞或CD 8杀伤T细胞的相互排斥的细胞命运决定发生。这些T细胞亚群不被认为重定向其他谱系。我们发现维甲酸和转化生长因子-β1以Runx 3依赖的方式促进CD 4 T细胞向CD 8 αα T细胞的分化。这些细胞被推断为属于免疫调节细胞群，因为已知CD 8 αα+TCRαβ T细胞亚群抑制活化的T细胞，并且具有Runx 3 −/− T细胞的小鼠在从实验性过敏性脑脊髓炎恢复期间表现出缺陷。我们的研究结果表明，CD 4 T细胞通过促进和减弱在控制免疫反应中起着重要作用。因此，我们预计，阐明这一过程的机制将提供见解，导致自身免疫和免疫缺陷疾病的治疗。
Mutually exclusive cell fate determination of CD4 helper or CD8 killer T cells occurs in the thymus. These T-cell subsets are not believed to redirect other lineages. Here we showed that retinoic acid and transforming growth factor-β1 promoted the differentiation of CD8αα T cells from CD4 T cells in a Runx3-dependent manner. These cells were inferred to belong to immunoregulatory populations because subpopulations of CD8αα+TCRαβ T cells are known to suppress activated T cells, and mice with Runx3−/− T cells showed defects during recovery from experimental allergic encephalomyelitis. Our results demonstrate that CD4 T cells play fundamental roles in controlling immune reactions through promotion and attenuation. We accordingly anticipate that clarifying the mechanisms underlying this process will provide insights leading to autoimmune and immunodeficiency disease therapies.
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影响因子：
32.4
作者：
Hall JA;Cannons JL;Grainger JR;Dos Santos LM;Hand TW;Naik S;Wohlfert EA;Chou DB;Oldenhove G;Robinson M;Grigg ME;Kastenmayer R;Schwartzberg PL;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
15.3
作者：
Das, G;Janeway, CA
通讯作者：
Janeway, CA
影响因子：
15.3
作者：
Pino-Lagos, Karina;Guo, Yanxia;Noelle, Randolph J.
通讯作者：
Noelle, Randolph J.
影响因子：
56.9
作者：
Mucida, Daniel;Park, Yunji;Cheroutre, Hilde
通讯作者：
Cheroutre, Hilde
影响因子：
56.9
作者：
KOH, DR;FUNGLEUNG, WP;MAK, TW
通讯作者：
MAK, TW