Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia.
Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia.
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DOI：
10.3389/fnhum.2013.00088
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发表时间：
2013
影响因子：
2.9
通讯作者：
Uhlhaas PJ
中科院分区：
文献类型：
--
作者：
Grützner C;Wibral M;Sun L;Rivolta D;Singer W;Maurer K;Uhlhaas PJ
精神分裂症的病理生理学的当前理论集中于神经活动的异常时间协调。伽马波段范围（>25 Hz）的振荡特别令人感兴趣，因为它们在局部皮层网络中建立了非常精确的同步。然而，高伽马（>60 Hz）振荡对病理生理学的贡献还不太确定。为了解决这个问题，我们记录了脑磁图（MEG）数据，从16个慢性精神分裂症患者和16个控制在感知穆尼脸。在25-150 Hz频率范围内分析MEG数据。患者表现出升高的反应时间和降低检测率在感知直立的门尼脸，而反应倒置刺激是完整的。精神分裂症患者对门尼面孔的加工受损，伴随着60-120 Hz之间的频谱功率显著降低（效应量：d = 1.26），这与混乱的症状相关（r =-0.72）。我们的研究结果表明，赤字高γ-波段振荡测量MEG是一个敏感的标记异常皮质功能的精神分裂症，这表明一个重要方面的疾病的病理生理。
Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25–150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60–120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = −0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder.
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影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.
DOI：
10.1523/jneurosci.0640-09.2009
发表时间：
2009-10-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jutras MJ;Fries P;Buffalo EA
通讯作者：
Buffalo EA
影响因子：
4.7
作者：
Krishnan, GP;Vohs, JL;O'Donnell, BF
通讯作者：
O'Donnell, BF
影响因子：
5.3
作者：
Haenschel, Corinna;Bittner, Robert A.;Rodriguez, Eugenio
通讯作者：
Rodriguez, Eugenio