The intersection between response inhibition and substance use among adolescents.
The intersection between response inhibition and substance use among adolescents.
复制标题
青少年反应抑制和物质使用之间的交叉点。
DOI：
10.1016/j.addbeh.2017.11.043
复制
发表时间：
2018
影响因子：
4.4
通讯作者：
FeldsteinEwing,SarahW
中科院分区：
文献类型：
--
作者：
RømerThomsen,Kristine;BlomOsterland,Tine;Hesse,Morten;FeldsteinEwing,SarahW
与成功参与反应抑制的能力相关的问题被认为是发生物质使用障碍（SUD）的危险因素，但证据主要是横截面的。在这篇评论中，我们认为最近对反应抑制多模式测量的纵向研究可以提高对反应抑制如何与青少年物质使用交叉的理解。大多数停止信号研究表明，较慢的反应抑制可以预测物质使用的进展，一项多中心研究显示，额顶叶活动越大，表明风险越大。大多数 Go-NoGo 研究表明，反应抑制期间前额叶皮层区域的激活迟缓可以预测物质使用的进展，而委托错误在识别处于危险中的青少年方面效果较差。研究在受试者人群、结果测量、统计方法和大胆反应对比方面存在差异，这对比较和概括研究结果的能力提出了挑战。我们鼓励全球的研究团队进行多模式、纵向研究，以大样本量评估大脑功能，并在可能的情况下，在大量物质使用可能模糊对研究结果的解释之前进行。对这些不断增长的文献进行系统回顾和荟萃分析也是未来研究的重要目标。
Problems related to the capacity to successfully engage response inhibition are considered a risk factor for the development of substance use disorders (SUDs), but the evidence has been predominantly cross-sectional. In this commentary, we argue that recent longitudinal studies with multi-modal measures of response inhibition can improve understanding of how response inhibition may intersect with substance use among adolescents. Most Stop-Signal studies suggest that slower response inhibition predicts substance use progressions, with one multi-site study showing greater fronto-parietal activity indicative of risk. Most Go-NoGo studies suggest that blunted activation of prefrontal cortical areas during response inhibition predicts substance use progressions, while commission errors are less effective in identifying adolescents at risk. Studies differ in subject populations, outcome measures, statistical methods, and BOLD response contrasts, which challenge the capacity to compare and generalize findings. We encourage research teams throughout the globe to undertake multi-modal, longitudinal studies to assess brain functioning with large sample sizes, and when possible, before significant substance use potentially obscures interpretation of findings. Systematic review and meta-analysis of this growing literature are also important goals for future research.
登录
查看更多内容
影响因子：
4.4
作者：
Mahmood, O. M.;Goldenberg, D.;Thayer, R.;Migliorini, R.;Simmons, A. N.;Tapert, S. F.
通讯作者：
Tapert, S. F.
DOI：
10.1097/01.chi.0000199028.76452.a9
发表时间：
2006-04-01
影响因子：
13.3
作者：
Nigg, JT;Wong, MM;Zucker, RA
通讯作者：
Zucker, RA
DOI：
10.1176/appi.ajp.2016.15121587
发表时间：
2017-02-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Squeglia LM;Ball TM;Jacobus J;Brumback T;McKenna BS;Nguyen-Louie TT;Sorg SF;Paulus MP;Tapert SF
通讯作者：
Tapert SF
影响因子：
4.2
作者：
Heitzeg, Mary M.;Nigg, Joel T.;Hardee, Jillian E.;Soules, Mary;Steinberg, Davia;Zubieta, Jon-Kar;Zucker, Robert A.
通讯作者：
Zucker, Robert A.