Adolescents' fMRI activation to a response inhibition task predicts future substance use.
Adolescents' fMRI activation to a response inhibition task predicts future substance use.
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DOI：
10.1016/j.addbeh.2012.07.012
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发表时间：
2013-01
影响因子：
4.4
通讯作者：
Tapert, S. F.
中科院分区：
文献类型：
--
作者：
Mahmood, O. M.;Goldenberg, D.;Thayer, R.;Migliorini, R.;Simmons, A. N.;Tapert, S. F.
行为调控缺失可能是青少年物质使用障碍的危险因素。大脑中对认知控制至关重要的区域的异常与未来更密集和更有问题的物质使用有关(例如。这项研究的目的是检验在青春期中期测量的大脑对抑制任务的反应可以在多大程度上预测18个月后的物质使用。年龄在16-19岁的青少年(N=80)在项目基线的fMRI中执行Go/no-Go反应抑制任务，并在18个月后对药物使用和依赖症状进行详细的访谈。参与者是39名高频吸毒者和41名人口统计学上相似的低频吸毒者(基线时，分别为458次和2次平均终身吸毒)。在所有受试者中，no-go试验在前额叶腹内侧皮质和包括左角回和缘上回在内的区域产生了显著的神经反应增加(p(Fwe)<；01，簇阈值≥30体素)。较少的腹内侧额叶激活，但较多的左角回激活，预示着在接下来的18个月中物质使用和依赖症状的水平更高，特别是对于那些在青春期中期频繁使用的人(p<；0.05)。这些发现与表明认知控制障碍与物质使用密切相关的研究是一致的。我们发现基线时的非典型激活模式与18个月后的物质使用行为之间存在预测关系，特别是在有大量使用史的青少年中。
Deficient behavioral regulation may be a risk factor for substance use disorders in adolescents. Abnormalities in brain regions critical to cognitive control have been linked to more intense and problematic future substance use (e.g.,. The goal of this study was to examine the degree to which brain response to an inhibition task measured in mid-adolescence can predict substance use 18 months later. Adolescents aged 16–19 (N=80) performed a go/no-go response inhibition task during fMRI at project baseline, and were followed 18 months later with a detailed interview on substance use and dependence symptoms. Participants were 39 high frequency users and 41 demographically similar low frequency users (458 versus 2 average lifetime drug use occasions at baseline, respectively). Across all subjects, no-go trials produced significant increases in neural response in the ventromedial prefrontal cortex and a region including the left angular and supramarginal gyri (p(FWE)<.01, cluster threshold ≥30 voxels). Less ventromedial prefrontal activation but more left angular gyrus activation predicted higher levels of substance use and dependence symptoms in the following 18 months, particularly for those who were high frequency users in mid-adolescence (p<.05). These findings are consistent with studies showing that impairments in cognitive control have strong associations with substance use. We found a predictive relationship between atypical activation patterns at baseline and substance use behavior 18 months later, particularly among adolescents with histories of previous heavy use.
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影响因子：
3.4
作者：
Lawrence, Andrew J.;Luty, Jason;Bogdan, Nadine A.;Sahakian, Barbara J.;Clark, Luke
通讯作者：
Clark, Luke
影响因子：
3.3
作者：
BANDETTINI, PA;JESMANOWICZ, A;HYDE, JS
通讯作者：
HYDE, JS
影响因子：
7.6
作者：
Kosten, TR;Scanley, BE;Wexler, BE
通讯作者：
Wexler, BE
影响因子：
2.5
作者：
Bava, Sunita;Jacobus, Joanna;Mahmood, Omar;Yang, Tony T.;Tapert, Susan F.
通讯作者：
Tapert, Susan F.
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW