Left middle frontal gyrus response to inhibitory errors in children prospectively predicts early problem substance use.
Left middle frontal gyrus response to inhibitory errors in children prospectively predicts early problem substance use.
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DOI：
10.1016/j.drugalcdep.2014.05.002
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发表时间：
2014-08-01
影响因子：
4.2
通讯作者：
Zucker, Robert A.
中科院分区：
文献类型：
--
作者：
Heitzeg, Mary M.;Nigg, Joel T.;Hardee, Jillian E.;Soules, Mary;Steinberg, Davia;Zubieta, Jon-Kar;Zucker, Robert A.
物质使用障碍（SUD）的核心脆弱性特征是行为去抑制。错误处理是抑制控制的一个核心方面，决定了自适应调整的性能，但它是一个很大程度上被忽视的方面去抑制，因为它涉及到SUD的风险。我们调查了成功和失败的抑制过程中大脑激活的差异是否预示着早期的问题物质使用。45名9-12岁的奥尔兹在进行/不进行任务期间接受了功能性MRI扫描。然后，他们被跟踪了大约4年，完成了对药物使用的评估。在3-8岁、9-12岁和11-13岁时测量了外化行为。年龄在13-16岁之间的吸毒或酗酒的参与者（n=13;问题用户组）按性别，年龄和酗酒家族史与非物质使用儿童（n=13;非用户组）进行单独匹配。剩下的19名参与者提供了一个独立的样本，从中产生无偏的区域的利益，在问题的用户和非用户组的假设检验。与基线相比，在正确抑制期间未观察到组间激活差异。一个显着的差异出现在左额中回（LMFG）激活失败的抑制与正确的抑制相比，与问题用户组表现出钝化激活。问题使用者组在11-13岁时也有更多的外化问题。Logistic回归发现，激活LMFG显着预测组成员以上的外化问题。在表现错误过程中LMFG激活减弱可能是适当适应行为问题的基础，导致行为控制不足，早期问题物质使用和SUD风险增加。
A core vulnerability trait for substance use disorder (SUD) is behavioral disinhibition. Error processing is a central aspect of inhibitory control that determines adaptive adjustment of performance; yet it is a largely overlooked aspect of disinhibition as it relates to risk for SUD. We investigated whether differences in brain activation during both successful and failed inhibition predicts early problem substance use. Forty-five 9–12 year olds underwent a functional MRI scan during a go/no-go task. They were then followed over approximately 4 years, completing assessments of substance use. Externalizing behavior was measured at ages 3–8, 9–12 and 11–13. Participants with drug use or problem alcohol use by ages 13–16 (n=13; problem-user group) were individually matched by gender, age, and family history of alcoholism with non-substance-using children (n=13; non-user group). The remaining 19 participants provided an independent sample from which to generate unbiased regions-of-interest for hypothesis testing in the problem-user and non-user groups. No differences were observed between groups in activation during correct inhibition compared with baseline. A significant difference arose in left middle frontal gyrus (LMFG) activation during failed inhibition compared with correct inhibition, with the problem-user group demonstrating blunted activation. The problem-user group also had more externalizing problems at ages 11–13. Logistic regression found that activation of LMFG significantly predicted group membership over and above externalizing problems. Blunted LMFG activation during performance errors may underlie problems adapting behavior appropriately, leading to undercontrolled behavior, early problem substance use and increased risk for SUD.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
5.7
作者：
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通讯作者：
Smith, S
影响因子：
3.7
作者：
Durston, S;Davidson, MC;Casey, BJ
通讯作者：
Casey, BJ
DOI：
10.1097/01.chi.0000199028.76452.a9
发表时间：
2006-04-01
影响因子：
13.3
作者：
Nigg, JT;Wong, MM;Zucker, RA
通讯作者：
Zucker, RA