Ocular pseudoexfoliation syndrome and vascular disease: a systematic review and meta-analysis.
Ocular pseudoexfoliation syndrome and vascular disease: a systematic review and meta-analysis.
复制标题
眼假性剥脱综合征和血管疾病：系统回顾和荟萃分析
DOI：
10.1371/journal.pone.0092767
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang W;He M;Zhou M;Zhang X
Objective Many studies have assessed the association between ocular pseudoexfoliation syndrome (PEX) and vascular disease and produced controversial results. We performed a meta-analysis of epidemiologic studies to evaluate this relationship. Methods Eligible studies that reported the incidence of vascular disease among PEX and control groups were identified via computer searches and reviewing the reference lists of the key articles. The summary odds ratio (OR) and 95% confidence interval (CI) were pooled using a random-effects model. Meta-regression to assess heterogeneity by several covariates and a subgroup analysis on study design and population were performed. Publication bias was tested by Begg's funnel plot and Egger's regression test. Results Sixteen eligible studies involving 8,533 PEX patients and 135,720 control patients were included in the meta-analysis. All studies were performed primarily in whites with a mean age between 54.7 and 77.1 years. The overall combined ORs for patients with PEX compared with the reference group were 1.72 (95% CI: 1.31 to 2.26) for any vascular disease, 1.61 (95% CI: 1.22 to 2.14) for coronary heart disease, 1.59 (95% CI: 1.12 to 2.23) for cerebrovascular disease, and 2.48 (95% CI: 1.30 to 4.72) for aortic aneurysm. There was evidence of statistical heterogeneity; however, subgroup and sensitivity analyses showed this result to be robust. No evidence of publication bias was observed. Conclusions The overall current literature suggests that PEX was associated with increased risk of vascular disease. Because of the limitations of the included studies and meta-analysis, the findings need to be confirmed in future research via well-designed cohort studies.
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DOI：
10.4103/1947-2714.101987
发表时间：
2012-10
期刊：
North American journal of medical sciences
影响因子：
--
作者：
French DD;Margo CE;Harman LE
通讯作者：
Harman LE
影响因子：
1.8
作者：
Viso, Eloy;Teresa Rodriguez-Ares, Maria;Gude, Francisco
通讯作者：
Gude, Francisco
影响因子：
3.9
作者：
Andrikopoulos, G. K.;Mela, E. K.;Gartaganis, S. P.
通讯作者：
Gartaganis, S. P.
影响因子：
3.9
作者：
Praveen, M. R.;Shah, S. K.;Thomas, R.
通讯作者：
Thomas, R.
影响因子：
2
作者：
Djordjevic-Jocic, Jasmina;Jovanovic, Predrag;Rancic, Zoran
通讯作者：
Rancic, Zoran