Future Directions for Chemosensory Connectomes: Best Practices and Specific Challenges.

Future Directions for Chemosensory Connectomes: Best Practices and Specific Challenges.
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DOI:
10.3389/fnsys.2022.885304
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发表时间:
2022
影响因子:
3
通讯作者:
Fischmeister, Florian Ph. S.
Fischmeister, Florian Ph. S.
中科院分区:
医学3区
文献类型:
--
作者:
Veldhuizen, Maria G.;Cecchetto, Cinzia;Fjaeldstad, Alexander W.;Farruggia, Michael C.;Hartig, Renee;Nakamura, Yuko;Pellegrino, Robert;Yeung, Andy W. K.;Fischmeister, Florian Ph. S.

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生态化学感觉刺激几乎总是会引起不止一种感觉系统的反应。此外,任何感觉处理都是沿着大脑区域的层次结构进行的。到目前为止,化学感应神经成像领域的主导研究是单独检查大脑区域的作用。然而,为了完全理解化学感觉的神经处理,我们还必须检查区域之间的相互作用。总的来说,连接方法的使用在神经影像领域有所增加,为视觉、听觉和触觉等物理感觉处理提供了重要的见解。在化学感觉神经成像中也观察到了类似的趋势,然而,这些已建立的技术在很大程度上并未严格应用于化学感觉的成像研究,从而导致网络洞察被忽视。在本文中,我们首先重点介绍化学感应连接组学方面的一些最新工作,并总结了不同的连接组学技术。然后,我们概述了化学感应连接组神经影像研究的具体挑战。最后,我们回顾了一般连接组学和神经影像学领域的最佳实践。我们建议未来的研究开发或使用以下我们认为是改善化学感应连接组学的关键方法:(1)优化研究设计,(2)报告指南,(3)脑分区共识,(4)联合研究,以及(5)数据共享。
Ecological chemosensory stimuli almost always evoke responses in more than one sensory system. Moreover, any sensory processing takes place along a hierarchy of brain regions. So far, the field of chemosensory neuroimaging is dominated by studies that examine the role of brain regions in isolation. However, to completely understand neural processing of chemosensation, we must also examine interactions between regions. In general, the use of connectivity methods has increased in the neuroimaging field, providing important insights to physical sensory processing, such as vision, audition, and touch. A similar trend has been observed in chemosensory neuroimaging, however, these established techniques have largely not been rigorously applied to imaging studies on the chemical senses, leaving network insights overlooked. In this article, we first highlight some recent work in chemosensory connectomics and we summarize different connectomics techniques. Then, we outline specific challenges for chemosensory connectome neuroimaging studies. Finally, we review best practices from the general connectomics and neuroimaging fields. We recommend future studies to develop or use the following methods we perceive as key to improve chemosensory connectomics: (1) optimized study designs, (2) reporting guidelines, (3) consensus on brain parcellations, (4) consortium research, and (5) data sharing.
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