The Mechanisms and Boundary Conditions of Drug Memory Reconsolidation.
The Mechanisms and Boundary Conditions of Drug Memory Reconsolidation.
复制标题
药物记忆重建的机制和边界条件
DOI：
10.3389/fnins.2021.717956
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Yan J
中科院分区：
文献类型：
--
作者：
Chen L;Yan H;Wang Y;He Z;Leng Q;Huang S;Wu F;Feng X;Yan J
药物成瘾可以被视为一种以复发为特征的适应不良学习障碍。因此，破坏与药物有关的记忆可能是改善成瘾治疗的一种方法。过去二十年的开创性研究表明，巩固的记忆不是静态的，而是可以在检索后重新巩固，从而为成瘾治疗提供了候选途径。已知边缘-皮质纹状体系统在药物记忆印迹的编码中起着至关重要的作用。该系统中的特定结构对记忆重新巩固的过程有不同的贡献，使其成为预防复发的潜在目标。此外，由于分子过程在记忆再巩固期间也是活跃的，因此可以使用遗忘剂来减弱药物记忆。在这篇综述中，我们主要集中在大脑结构参与存储药物记忆印迹，以及参与药物记忆再巩固的分子过程。值得注意的是，我们描述了关于限制记忆再巩固治疗潜力的边界条件的报告。此外，我们还讨论了可以用来修改存储记忆的原则。最后，我们强调了基于再巩固策略的挑战，但最后对药物复吸预防的再巩固理论的发展持乐观态度。
Drug addiction can be seen as a disorder of maladaptive learning characterized by relapse. Therefore, disrupting drug-related memories could be an approach to improving therapies for addiction. Pioneering studies over the last two decades have revealed that consolidated memories are not static, but can be reconsolidated after retrieval, thereby providing candidate pathways for the treatment of addiction. The limbic–corticostriatal system is known to play a vital role in encoding the drug memory engram. Specific structures within this system contribute differently to the process of memory reconsolidation, making it a potential target for preventing relapse. In addition, as molecular processes are also active during memory reconsolidation, amnestic agents can be used to attenuate drug memory. In this review, we focus primarily on the brain structures involved in storing the drug memory engram, as well as the molecular processes involved in drug memory reconsolidation. Notably, we describe reports regarding boundary conditions constraining the therapeutic potential of memory reconsolidation. Furthermore, we discuss the principles that could be employed to modify stored memories. Finally, we emphasize the challenge of reconsolidation-based strategies, but end with an optimistic view on the development of reconsolidation theory for drug relapse prevention.
登录
查看更多内容
影响因子：
3.4
作者：
Arguello, Amy A.;Hodges, Matthew A.;Wells, Audrey M.;Lara, Honorio, III;Xie, Xiaohu;Fuchs, Rita A.
通讯作者：
Fuchs, Rita A.
影响因子：
2.7
作者：
Jarome, Timothy J.;Lubin, Farah D.
通讯作者：
Lubin, Farah D.
DOI：
10.1101/lm.035543.114
发表时间：
2014-09
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Exton-McGuinness MT;Patton RC;Sacco LB;Lee JL
通讯作者：
Lee JL
从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
DOI：
10.1523/jneurosci.2829-20.2021
发表时间：
2021-03-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Campbell RR;Kramár EA;Pham L;Beardwood JH;Augustynski AS;López AJ;Chitnis OS;Delima G;Banihani J;Matheos DP;Wood MA
通讯作者：
Wood MA