Epigenetic mechanisms of memory formation and reconsolidation.
Epigenetic mechanisms of memory formation and reconsolidation.
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DOI：
10.1016/j.nlm.2014.08.002
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发表时间：
2014-11
影响因子：
2.7
通讯作者：
Lubin, Farah D.
中科院分区：
文献类型：
--
作者：
Jarome, Timothy J.;Lubin, Farah D.
记忆巩固涉及神经元中基因的转录控制，以稳定新形成的记忆。在提取之后，一个曾经巩固的记忆变得不稳定，并再次需要基因转录的变化来重新稳定，这个过程被称为重新巩固。了解巩固和再巩固过程中基因转录的分子机制可以为正常记忆形成和与精神疾病相关的记忆功能障碍提供重要的见解。在过去的十年中，修饰的表观遗传标记，如DNA甲基化和组蛋白的翻译后修饰已成为关键的转录调控基因表达在最初的记忆形成和检索后。鉴于在这一令人兴奋的研究领域迅速增长的文献，我们在这里研究了最近和最新的证据，证明记忆的获得和提取如何在巩固和再巩固阶段触发表观遗传变化，以影响行为。特别是，我们专注于再巩固过程中，我们讨论了已经确定的表观遗传调节记忆再巩固过程中的基因转录，同时探索其他潜在的表观遗传修饰，也可能参与，并扩大这些表观遗传修饰可能是如何精确和时间控制的重要信号级联反应的再巩固过程中至关重要的。最后，我们探讨的可能性，表观遗传机制可能有助于调节系统或电路水平的再巩固过程，并可能参与检索依赖的记忆更新。因此，我们提出，表观遗传机制协调神经元基因转录的变化，不仅在最初的记忆巩固阶段，但触发检索，以调节分子和细胞过程中的记忆再巩固。
Memory consolidation involves transcriptional control of genes in neurons to stabilize a newly formed memory. Following retrieval, a once consolidated memory destabilizes and again requires gene transcription changes in order to restabilize, a process referred to as reconsolidation. Understanding the molecular mechanisms of gene transcription during the consolidation and reconsolidation processes could provide crucial insights into normal memory formation and memory dysfunction associated with psychiatric disorders. In the past decade, modifications of epigenetic markers such as DNA methylation and posttranslational modifications of histone proteins have emerged as critical transcriptional regulators of gene expression during initial memory formation and after retrieval. In light of the rapidly growing literature in this exciting area of research, we here examine the most recent and latest evidence demonstrating how memory acquisition and retrieval trigger epigenetic changes during the consolidation and reconsolidation phases to impact behavior. In particular we focus on the reconsolidation process, where we discuss the already identified epigenetic regulators of gene transcription during memory reconsolidation, while exploring other potential epigenetic modifications that may also be involved, and expand on how these epigenetic modifications may be precisely and temporally controlled by important signaling cascades critical to the reconsolidation process. Finally, we explore the possibility that epigenetic mechanisms may serve to regulate a system or circuit level reconsolidation process and may be involved in retrieval-dependent memory updating. Hence, we propose that epigenetic mechanisms coordinate changes in neuronal gene transcription, not only during the initial memory consolidation phase, but are triggered by retrieval to regulate molecular and cellular processes during memory reconsolidation.
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影响因子：
2.7
作者：
Day, Jeremy J;Sweatt, J David
通讯作者：
Sweatt, J David
影响因子：
9.2
作者：
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影响因子：
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作者：
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Fuchs, Rita A.
影响因子：
1.9
作者：
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通讯作者：
Helmstetter, FJ
影响因子：
3.3
作者：
De Oliveira Alvares, L.;Crestani, A. P.;Quillfeldt, J. A.
通讯作者：
Quillfeldt, J. A.