Comparing the genomes of Helicobacter pylori clinical strain UM032 and Mice-adapted derivatives.
Comparing the genomes of Helicobacter pylori clinical strain UM032 and Mice-adapted derivatives.
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比较幽门螺杆菌临床菌株UM032和小鼠适应的衍生物的基因组。
DOI：
10.1186/1757-4749-5-25
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发表时间：
2013
期刊：
影响因子：
4.2
通讯作者：
Vadivelu J
中科院分区：
文献类型：
--
作者：
Khosravi Y;Rehvathy V;Wee WY;Wang S;Baybayan P;Singh S;Ashby M;Ong J;Amoyo AA;Seow SW;Choo SW;Perkins T;Chua EG;Tay A;Marshall BJ;Loke MF;Goh KL;Pettersson S;Vadivelu J
幽门螺杆菌是一种革兰氏阴性细菌，持续感染人类胃，引起慢性炎症。其确切的发病机制尚未完全清楚。虽然不是H. pylori小鼠感染模型在建立H.幽门。本研究首次对临床H.使用PacBio单分子实时（SMRT）技术对幽门螺杆菌菌株UM032和小鼠适应的衍生物298和299进行测序。在这里，我们描述了UM032（1，599，441 bp）、298（1，604，216 bp）和299（1，601，149 bp）的单个重叠群。初步分析表明，H. pylori基因组通过其限制性修饰系统可能决定其宿主特异性和适应性。这些基因组序列的可用性将有助于提高我们目前对H.幽门。
Helicobacter pylori is a Gram-negative bacterium that persistently infects the human stomach inducing chronic inflammation. The exact mechanisms of pathogenesis are still not completely understood. Although not a natural host for H. pylori, mouse infection models play an important role in establishing the immunology and pathogenicity of H. pylori. In this study, for the first time, the genome sequences of clinical H. pylori strain UM032 and mice-adapted derivatives, 298 and 299, were sequenced using the PacBio Single Molecule, Real-Time (SMRT) technology. Here, we described the single contig which was achieved for UM032 (1,599,441 bp), 298 (1,604,216 bp) and 299 (1,601,149 bp). Preliminary analysis suggested that methylation of H. pylori genome through its restriction modification system may be determinative of its host specificity and adaptation. Availability of these genomic sequences will aid in enhancing our current level of understanding the host specificity of H. pylori.
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影响因子：
4.2
作者：
Kulkarni G;Dhotre D;Dharne M;Shetty S;Chowdhury S;Misra V;Misra S;Patole M;Shouche Y
通讯作者：
Shouche Y
影响因子：
29.4
作者：
Lee, A;ORourke, J;Dixon, MF
通讯作者：
Dixon, MF
影响因子：
4.4
作者：
Aziz RK;Bartels D;Best AA;DeJongh M;Disz T;Edwards RA;Formsma K;Gerdes S;Glass EM;Kubal M;Meyer F;Olsen GJ;Olson R;Osterman AL;Overbeek RA;McNeil LK;Paarmann D;Paczian T;Parrello B;Pusch GD;Reich C;Stevens R;Vassieva O;Vonstein V;Wilke A;Zagnitko O
通讯作者：
Zagnitko O
影响因子：
14.9
作者：
Overbeek R;Begley T;Butler RM;Choudhuri JV;Chuang HY;Cohoon M;de Crécy-Lagard V;Diaz N;Disz T;Edwards R;Fonstein M;Frank ED;Gerdes S;Glass EM;Goesmann A;Hanson A;Iwata-Reuyl D;Jensen R;Jamshidi N;Krause L;Kubal M;Larsen N;Linke B;McHardy AC;Meyer F;Neuweger H;Olsen G;Olson R;Osterman A;Portnoy V;Pusch GD;Rodionov DA;Rückert C;Steiner J;Stevens R;Thiele I;Vassieva O;Ye Y;Zagnitko O;Vonstein V
通讯作者：
Vonstein V
影响因子：
5.8
作者：
O'Rourke, JL;Lee, A
通讯作者：
Lee, A