Evolution of glutamatergic signaling and synapses.
Evolution of glutamatergic signaling and synapses.
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DOI：
10.1016/j.neuropharm.2021.108740
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发表时间：
2021-11-01
影响因子：
4.7
通讯作者：
Romanova, Daria Y.
中科院分区：
文献类型：
--
作者：
Moroz, Leonid L.;Nikitin, Mikhail A.;Policar, Pavlin G.;Kohn, Andrea B.;Romanova, Daria Y.
关键词：
谷氨酸（Glu）是哺乳动物大脑中主要的兴奋性递质。但是，我们对这种适应的进化史知之甚少，包括首先选择l-谷氨酸作为信号分子。在这里，我们使用比较代谢组学和基因组数据来重建谷氨酸能信号的谱系。葡萄糖介导的通讯的起源可以追溯到原始的氮和碳代谢途径。l -谷氨酸的多种化学性质使其作为最丰富的代谢物之一，处于细胞生物化学的十字路口。从那时起，创新成倍增长。许多应激因素或损伤可增加细胞外谷氨酸浓度，这导致了在细菌和古细菌中快速检测谷氨酸的模块化分子系统的发展。在真核生物中发现了20多个不同的嗜离子性谷氨酸受体（iGluRs）家族。iGluRs结构域组成与真核生物多细胞起源有关。尽管L-Glu在早期分支后生动物中作为神经肌肉递质被吸收，但它主要是一种非神经元信使，有可能谷氨酸突触进化不止一次。此外，无脊椎动物的谷氨酸能突触的分子分泌复杂性可以超过它们的脊椎动物。比较基因组学还揭示了后生动物中超过15个iGluRs亚家族。然而，大多数这种祖先多样性在脊椎动物谱系中已经丢失，保留了AMPA， Kainate， Delta和NMDA受体。皮质区谷氨酸突触的广泛扩张可能与复杂大脑代谢需求的增强和模块化神经元群中谷氨酸信号的区隔化有关。
Glutamate (Glu) is the primary excitatory transmitter in the mammalian brain. But, we know little about the evolutionary history of this adaptation, including the selection of l-glutamate as a signaling molecule in the first place. Here, we used comparative metabolomics and genomic data to reconstruct the genealogy of glutamatergic signaling. The origin of Glu-mediated communications might be traced to primordial nitrogen and carbon metabolic pathways. The versatile chemistry of L-Glu placed this molecule at the crossroad of cellular biochemistry as one of the most abundant metabolites. From there, innovations multiplied. Many stress factors or injuries could increase extracellular glutamate concentration, which led to the development of modular molecular systems for its rapid sensing in bacteria and archaea. More than 20 evolutionarily distinct families of ionotropic glutamate receptors (iGluRs) have been identified in eukaryotes. The domain compositions of iGluRs correlate with the origins of multicellularity in eukaryotes. Although L-Glu was recruited as a neuro-muscular transmitter in the early-branching metazoans, it was predominantly a non-neuronal messenger, with a possibility that glutamatergic synapses evolved more than once. Furthermore, the molecular secretory complexity of glutamatergic synapses in invertebrates (e.g., Aplysia) can exceed their vertebrate counterparts. Comparative genomics also revealed 15+ subfamilies of iGluRs across Metazoa. However, most of this ancestral diversity had been lost in the vertebrate lineage, preserving AMPA, Kainate, Delta, and NMDA receptors. The widespread expansion of glutamate synapses in the cortical areas might be associated with the enhanced metabolic demands of the complex brain and compartmentalization of Glu signaling within modular neuronal ensembles.
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影响因子：
15.9
作者：
Bosch TCG;Klimovich A;Domazet-Lošo T;Gründer S;Holstein TW;Jékely G;Miller DJ;Murillo-Rincon AP;Rentzsch F;Richards GS;Schröder K;Technau U;Yuste R
通讯作者：
Yuste R
DOI：
10.1073/pnas.1914772117
发表时间：
2020-04-21
影响因子：
11.1
作者：
Bigman, Lavi S.;Levy, Yaakov
通讯作者：
Levy, Yaakov
DOI：
10.1073/pnas.0605863103
发表时间：
2006-08-29
影响因子：
11.1
作者：
Breslow, Ronald;Levine, Mindy S.
通讯作者：
Levine, Mindy S.
影响因子：
4.2
作者：
Brunengraber, Henri;Roe, Charles R.
通讯作者：
Roe, Charles R.
影响因子：
16.2
作者：
Armand EJ;Li J;Xie F;Luo C;Mukamel EA
通讯作者：
Mukamel EA