Aging Brain and Hearing: A Mini-Review.
Aging Brain and Hearing: A Mini-Review.
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DOI：
10.3389/fnagi.2021.791604
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发表时间：
2021
影响因子：
4.8
通讯作者：
Nakamura A
中科院分区：
文献类型：
--
作者：
Uchida Y;Nishita Y;Otsuka R;Sugiura S;Sone M;Yamasoba T;Kato T;Iwata K;Nakamura A
脑储备是老龄医学领域研究者们非常感兴趣的课题。有些人保留了良好的认知功能，直到他们完成他们的生活，尽管显着的大脑病理。解释这一悖论的一个概念是储备假说，包括脑储备假设一种虚拟的能力，以减轻神经病理变化的影响，并通过充分利用认知和补偿过程灵活有效地减少对临床症状的影响。储备能力的替代指标之一是脑容量。痴呆症和听力损失相互关联的证据一直在稳步积累，年龄相关性听力损失是痴呆症最有希望的可改变的风险因素之一。针对老年人大脑相对听觉功能的影像学分析研究逐渐增多。已经进行了几项形态学研究，以了解听力损失和脑容量之间的关系。在这篇简短的综述中，我们简要概述了脑储备的概念，然后对脑形态学和听力损失/听力补偿的研究进行了简短的回顾，包括我们以前的研究结果，即中年后的听力损失可能会影响海马和初级听皮层萎缩。
Brain reserve is a topic of great interest to researchers in aging medicine field. Some individuals retain well-preserved cognitive function until they fulfill their lives despite significant brain pathology. One concept that explains this paradox is the reserve hypothesis, including brain reserve that assumes a virtual ability to mitigate the effects of neuropathological changes and reduce the effects on clinical symptoms flexibly and efficiently by making complete use of the cognitive and compensatory processes. One of the surrogate measures of reserve capacity is brain volume. Evidence that dementia and hearing loss are interrelated has been steadily accumulating, and age-related hearing loss is one of the most promising modifiable risk factors of dementia. Research focused on the imaging analysis of the aged brain relative to auditory function has been gradually increasing. Several morphological studies have been conducted to understand the relationship between hearing loss and brain volume. In this mini review, we provide a brief overview of the concept of brain reserve, followed by a small review of studies addressing brain morphology and hearing loss/hearing compensation, including the findings obtained from our previous study that hearing loss after middle age could affect hippocampal and primary auditory cortex atrophy.
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影响因子：
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作者：
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