Wireless microelectrode arrays for selective and chronically stable peripheral nerve stimulation for hindlimb movement.
Wireless microelectrode arrays for selective and chronically stable peripheral nerve stimulation for hindlimb movement.
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DOI：
10.1088/1741-2552/ac2bb8
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发表时间：
2021-10-14
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
最大限度地提高植入神经接口的稳定性对于开发有效的神经和神经肌肉疾病治疗方法至关重要。我们的研究旨在开发一种稳定的神经接口，使用无线通信和神经束内微电极来提供对神经组织的高度选择性刺激。我们将无线浮动微电极阵列植入6只大鼠的左侧坐骨神经。在38周的植入期内，我们记录了每个植入电极处诱发的刺激阈值和运动。我们还跟踪了每只动物对感官刺激的反应和两种不同行走任务的表现。坐骨神经内的微电极阵列的存在并没有引起后肢的任何明显的运动或感觉缺陷。用低至4.1 μA的电流刺激坐骨神经可诱发后肢的可见运动。在我们植入的96个电极中，大多数的维持电流低于20 μA，并且通过用束内微电极阵列刺激大鼠坐骨神经实现了可预测的跖屈和背屈的募集。此外，每个电极的运动募集模式在整个研究期间没有显著变化。在啮齿类动物外周神经中进行的为期9.5个月的广泛评估中，增强无线通信和低轮廓神经接口促进了后肢中高度稳定的运动募集阈值和精细运动控制。本研究的结果表明，此处测试的无线设备的使用可以扩展到需要选择性神经刺激和长期植入的其他应用。
Maximizing the stability of implanted neural interfaces will be critical to developing effective treatments for neurological and neuromuscular disorders. Our research aims to develop a stable neural interface using wireless communication and intrafascicular microelectrodes to provide highly selective stimulation of neural tissue. We implanted a wireless floating microelectrode array into the left sciatic nerve of six rats. Over a 38 week implantation period, we recorded stimulation thresholds and movements evoked at each implanted electrode. We also tracked each animal’s response to sensory stimuli and performance on two different walking tasks. Presence of the microelectrode array inside the sciatic nerve did not cause any obvious motor or sensory deficits in the hindlimb. Visible movement in the hindlimb was evoked by stimulating the sciatic nerve with currents as low as 4.1 μA. Thresholds for most of the 96 electrodes we implanted were below 20 μA, and predictable recruitment of plantar flexion and dorsiflexion was achieved by stimulating rat sciatic nerve with the intrafascicular microelectrode array. Further, motor recruitment patterns for each electrode did not change significantly throughout the study. Incorporating wireless communication and a low-profile neural interface facilitated highly stable motor recruitment thresholds and fine motor control in the hindlimb throughout an extensive 9.5 month assessment in rodent peripheral nerve. Results of this study indicate that use of the wireless device tested here could be extended to other applications requiring selective neural stimulation and chronic implantation.
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影响因子：
4.8
作者：
Deuis JR;Dvorakova LS;Vetter I
通讯作者：
Vetter I
影响因子：
4
作者：
通讯作者：
--
影响因子：
2.8
作者：
Delianides, Christopher;Tyler, Dustin;Triolo, Ronald
通讯作者：
Triolo, Ronald
DOI：
10.1109/tnsre.2015.2440768
发表时间：
2016-01-01
影响因子：
4.9
作者：
Badia, Jordi;Raspopovic, Stanisa;Navarro, Xavier
通讯作者：
Navarro, Xavier
影响因子：
64.8
作者：
Hochberg, Leigh R.;Serruya, Mijail D.;Donoghue, John P.
通讯作者：
Donoghue, John P.