Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.
Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.
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DOI：
10.1016/j.drugalcdep.2021.108561
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发表时间：
2021-04-01
影响因子：
4.2
通讯作者：
Harris AC
中科院分区：
文献类型：
--
作者：
Swain Y;Gewirtz JC;Harris AC
像其他形式的精神病理学一样，对阿片类药物成瘾的脆弱性受到广泛的个体差异的影响。动物行为模型在促进我们对疾病发展和治疗易感性的潜在机制的理解方面是有价值的。本综述概述了使用大鼠静脉注射（i.v.）自我给药（SA）模型测量阿片类药物成瘾脆弱性的行为预测因素的临床前工作。我们还强调了在临床前模型中研究阿片类药物成瘾脆弱性个体差异的几种新方法，这些方法可能具有更高的敏感性并导致更多临床相关的发现。在临床前文献中，各种行为特征与阿片SA之间的关系的证据是有限的。除了对阿片类药物激动剂/戒断效应的敏感性和应激反应性可能的例外，其他滥用药物（如感觉寻求、冲动性）的SA个体差异的预测因子不能预测大鼠对阿片类药物SA的易感性。对SA测量方法的改进以及多变量设计和统计的使用可以帮助确定阿片类药物SA的预测因素，并导致更多与阿片类药物成瘾易感性相关的临床研究。
Like other forms of psychopathology, vulnerability to opioid addiction is subject to wide individual differences. Animal behavioral models are valuable in advancing our understanding of mechanisms underlying vulnerability to the disorder’s development and amenability to treatment. This review provides an overview of preclinical work on behavioral predictors of opioid addiction vulnerability as measured using the intravenous (i.v.) self-administration (SA) model in rats. We also highlight several new approaches to studying individual differences in opioid addiction vulnerability in preclinical models that could have greater sensitivity and lead to more clinically relevant findings. Evidence for the relationship between various behavioral traits and opioid SA in the preclinical literature is limited. With the possible exceptions of sensitivity to opioid agonist/withdrawal effects and stress reactivity, predictors of individual differences in SA of other drugs of abuse (e.g. sensation-seeking, impulsivity) do not predict vulnerability to opioid SA in rats. Refinement of SA measures and the use of multivariate designs and statistics could help identify predictors of opioid SA and lead to more clinically relevant studies on opioid addiction vulnerability.
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影响因子：
4.2
作者：
Back SE;Gros DF;Price M;LaRowe S;Flanagan J;Brady KT;Davis C;Jaconis M;McCauley JL
通讯作者：
McCauley JL
影响因子：
2.7
作者：
Banna, Kelly M.;Back, Sudie E.;Do, Phong;See, Ronald E.
通讯作者：
See, Ronald E.
影响因子：
3.4
作者：
Bentzley, Brandon S.;Fender, Kimberly M.;Aston-Jones, Gary
通讯作者：
Aston-Jones, Gary
影响因子：
3.6
作者：
Anker, Justin J.;Perry, Jennifer L.;Gliddon, Luke A.;Carroll, Marilyn E.
通讯作者：
Carroll, Marilyn E.
影响因子：
2.7
作者：
BLANCHARD, RJ;YUDKO, EB;BLANCHARD, DC
通讯作者：
BLANCHARD, DC