The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat.
The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat.
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DOI：
10.3389/fnbeh.2021.760791
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发表时间：
2021
影响因子：
3
通讯作者：
Doucette WT
中科院分区：
文献类型：
--
作者：
Sullivan EDK;Locke LN;Wallin DJ;Khokhar JY;Bragg EM;Henricks AM;Doucette WT
尼古丁和饮酒在患有严重精神疾病（包括精神分裂症）（SCZ）的患者中非常普遍，这种同时发生可能会导致医学和精神病发病率恶化。虽然同时发生的SCZ的机械驱动因素，尼古丁的使用和饮酒尚不清楚，但新出现的证据表明，青春期使用药物的使用可能会增加发展精神疾病的可能性。当前的研究使用了SCZ的新生儿腹侧海马病变（NVHL）大鼠模型，该模型以前已证明它已经增强了尼古丁行为敏化，并随着青少年酒精的含量增加了酒精消耗。鉴于如何使用SCZ的青少年通常使用酒精，我们使用NVHL大鼠来确定接触青少年酒精如何影响成年后尼古丁行为敏化的发展。雄性Sprague-Dawley大鼠接受了NVHL手术或假手术（对照）手术，随后，每组一半被允许在青春期喝酒。在成年期评估尼古丁行为敏化，每天接受皮下注射尼古丁（0.5 mg/kg）的大鼠，持续3周，然后在2周后进行尼古丁挑战会议。我们证明，所有大鼠群都对尼古丁敏感，并且尼古丁行为敏化没有NVHL特异性的增加。我们还发现，NVHL大鼠似乎对尼古丁配对的上下文产生了敏感性，并且青少年酒精暴露阻止了这种上下文的敏感性。目前的发现表明，青春期暴露于酒精会影响成年NVHL大鼠（即上下文敏化）中表现出的行为。有趣的是，与先前的报道相比，NVHL组的尼古丁行为敏化水平不会改变。
Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those with schizophrenia (SCZ), and this co-occurrence can lead to a worsening of medical and psychiatric morbidity. While the mechanistic drivers of co-occurring SCZ, nicotine use and alcohol use are unknown, emerging evidence suggests that the use of drugs during adolescence may increase the probability of developing psychiatric disorders. The current study used the neonatal ventral hippocampal lesion (NVHL) rat model of SCZ, which has previously been shown to have enhanced nicotine behavioral sensitization and, following adolescent alcohol, increased alcohol consumption. Given how commonly alcohol is used by adolescents that develop SCZ, we used the NVHL rat to determine how exposure to adolescent alcohol impacts the development of nicotine behavioral sensitization in adulthood. Male Sprague-Dawley rats underwent the NVHL surgery or a sham (control) surgery and subsequently, half of each group was allowed to drink alcohol during adolescence. Nicotine behavioral sensitization was assessed in adulthood with rats receiving subcutaneous injections of nicotine (0.5 mg/kg) each day for 3 weeks followed by a nicotine challenge session 2 weeks later. We demonstrate that all groups of rats became sensitized to nicotine and there were no NVHL-specific increases in nicotine behavioral sensitization. We also found that NVHL rats appeared to develop sensitization to the nicotine paired context and that adolescent alcohol exposure blocked this context sensitization. The current findings suggest that exposure to alcohol during adolescence can influence behaviors that manifest in the adult NVHL rat (i.e., context sensitization). Interestingly, nicotine behavioral sensitization levels were not altered in the NVHL groups regardless of adolescent alcohol exposure in contrast to prior reports.
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影响因子：
11.3
作者：
Abdel-Baki, Amal;Ouellet-Plamondon, Clairelaine;Potvin, Stephane
通讯作者：
Potvin, Stephane
DOI：
10.1007/978-1-61779-157-4_1
发表时间：
2011-01-01
期刊：
ANIMAL MODELS OF SCHIZOPHRENIA AND RELATED DISORDERS
影响因子：
--
作者：
Chambers, R. Andrew;Lipska, Barbara K.
通讯作者：
Lipska, Barbara K.
影响因子：
3
作者：
Carrara-Nascimento, Priscila Fernandes;Hoffmann, Lucas Barbosa;Camarini, Rosana
通讯作者：
Camarini, Rosana
影响因子：
2.7
作者：
Beninger, Richard J.;Tuerke, Katharine J.;Jhamandas, Khem
通讯作者：
Jhamandas, Khem
影响因子：
3.8
作者：
BLOMQVIST, O;SODERPALM, B;ENGEL, JA
通讯作者：
ENGEL, JA