Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective.
Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective.
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DOI：
10.1080/10590501.2011.629974
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Ramesh A
中科院分区：
文献类型：
--
作者：
Diggs DL;Huderson AC;Harris KL;Myers JN;Banks LD;Rekhadevi PV;Niaz MS;Ramesh A
结肠癌在西方世界最为常见。在这些病例中，大多数没有家族病史，散发的基因损伤似乎在结肠肿瘤的发展中起重要作用。研究表明，环境因素，尤其是饮食，在胃肠道癌症的易感性中起着重要作用。因此，在制备过程中污染食物或饮食的环境化学物质在胃肠道癌症的发展中变得重要。多环芳烃（PAHs）是一类普遍存在的环境毒物。这些污染物通过食用受污染的食物、饮用水、吸入香烟烟雾、汽车尾气和职业环境中受污染的空气进入人体。在这些途径中，饮食摄入多环芳烃是人类接触的主要来源。虽然已经发表了许多关于多环芳烃及其毒性和乳腺癌或肺癌的能力的评论和书籍，但关于饮食，吸烟和其他因素对消化道癌症发展的贡献以及评估暴露于多环芳烃风险的策略的方面却很少受到关注。因此，本综述的重点是人类、动物模型和用于胃肠道癌症研究的细胞培养物中多环芳烃的膳食摄入量以及流行病学研究结果。生物利用度和生物转化过程，影响多环芳烃在体内的配置和胃肠道癌症的潜在致病机制，也进行了讨论。还强调了现有的数据差距和未来研究的范围。这一信息有望促进对暴露于环境致癌物引起的散发性胃肠道癌症机制的研究。
Cancers of the colon are most common in the Western world. In majority of these cases, there is no familial history and sporadic gene damage seems to play an important role in the development of tumors in the colon. Studies have shown that environmental factors, especially diet, play an important role in susceptibility to GI tract cancers. Consequently, environmental chemicals that contaminate food or diet during its preparation becomes important in the development of GI cancers. Polycyclic aromatic hydrocarbons (PAHs) are one such family of ubiquitous environmental toxicants. These pollutants enter the human body through consumption of contaminated food, drinking water, inhalation of cigarette smoke, automobile exhausts, and contaminated air from occupational settings. Among these pathways, dietary intake of PAHs constitutes a major source of exposure in humans. Although many reviews and books on PAHs and their ability to cause toxicity and breast or lung cancer have been published, aspects on contribution of diet, smoking and other factors towards development of digestive tract cancers and strategies to assess risk from exposure to PAHs have received much less attention. This review, therefore, focuses on dietary intake of PAHs in humans, animal models, and cell cultures used for GI cancer studies along with epidemiological findings. Bioavailability and biotransformation processes, which influence the disposition of PAHs in body and the underlying causative mechanisms of GI cancers, are also discussed. The existing data gaps and scope for future studies is also emphasized. This information is expected to stimulate research on mechanisms of sporadic GI cancers caused by exposure to environmental carcinogens.
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影响因子：
4.3
作者：
Bae, Jae-Sung;Jang, Kwang-Ho;Jin, Hee-Kyung
通讯作者：
Jin, Hee-Kyung
影响因子：
2.6
作者：
Al-Saleh, I.;Arif, J.;Mohamed, G.
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影响因子：
9.7
作者：
Cheng, JL;Futakuchi, M;Shirai, T
通讯作者：
Shirai, T
影响因子：
4.3
作者：
Chen, Yi-Ling;Fang, Jung-Hua;Shan, Yan-Shen
通讯作者：
Shan, Yan-Shen
DOI：
10.1080/01635581.2011.553021
发表时间：
2011
期刊：
Nutrition and cancer
影响因子：
--
作者：
Burnett-Hartman AN;Newcomb PA;Mandelson MT;Adams SV;Wernli KJ;Shadman M;Wurscher MA;Makar KW
通讯作者：
Makar KW