Chiral forces organize left-right patterning in C. elegans by uncoupling midline and anteroposterior axis.
Chiral forces organize left-right patterning in C. elegans by uncoupling midline and anteroposterior axis.
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DOI：
10.1016/j.devcel.2010.08.014
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发表时间：
2010-09-14
影响因子：
11.8
通讯作者：
Bao, Zhirong
中科院分区：
文献类型：
--
作者：
Pohl, Christian;Bao, Zhirong
左右（LR）图案是一个有趣的，但了解甚少的过程方面的双侧胚胎发生。我们报告了一个机制LR图案在C。胚胎的中线与前后轴分离。具体地说，八细胞胚胎建立了一条中线，该中线从AP轴倾斜，并将更多的细胞定位在左侧，从而允许随后的差异LR命运诱导。为了建立倾斜的中线，细胞表现出LR不对称突起和手动集体运动。这个过程，称为手性形态发生，涉及一对姐妹细胞之间的皮质收缩性的差异调节，这对姐妹细胞是双边对应物的命运，并通过非经典Wnt信号转导激活。手性形态发生的时间由一个邻居的姐妹对的细胞动力学沟，提供了一个发育时钟和收缩环和相邻细胞之间的意想不到的信号相互作用。
Left-right (LR) patterning is an intriguing but poorly understood process aspect of bilaterian embryogenesis. We report a mechanism for LR patterning in C. elegans in which the embryo uncouples its midline from the anteroposterior (AP) axis. Specifically, the eight-cell embryo establishes a midline that is tilted rightward from the AP axis and positions more cells on the left, allowing subsequent differential LR fate inductions. To establish the tilted midline, cells exhibit LR asymmetric protrusions and a handed collective movement. This process, termed chiral morphogenesis, involves differential regulation of cortical contractility between a pair of sister cells that are bilateral counterparts fate-wise, and is activated by non-canonical Wnt signaling. Chiral morphogenesis is timed by the cytokinetic furrow of a neighbor of the sister pair, providing a developmental clock and an unexpected signaling interaction between the contractile ring and adjacent cells.
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影响因子：
3
作者：
Boyle, Thomas J.;Bao, Zhirong;Murray, John I.;Araya, Carlos L.;Waterston, Robert H.
通讯作者：
Waterston, Robert H.
影响因子：
64.5
作者：
Lin, RL;Hill, RJ;Priess, JR
通讯作者：
Priess, JR
影响因子：
64.8
作者：
Kuroda, Reiko;Endo, Bunshiro;Shimizu, Miho
通讯作者：
Shimizu, Miho
影响因子：
48
作者：
Riedl, Julia;Crevenna, Alvaro H.;Wedlich-Soldner, Roland
通讯作者：
Wedlich-Soldner, Roland
DOI：
10.1002/ar.20872
发表时间：
2009-04
影响因子：
2
作者：
Cui, Cheng;Little, Charles D.;Rongish, Brenda J.
通讯作者：
Rongish, Brenda J.