AceTree: a tool for visual analysis of Caenorhabditis elegans embryogenesis.
AceTree: a tool for visual analysis of Caenorhabditis elegans embryogenesis.
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DOI：
10.1186/1471-2105-7-275
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发表时间：
2006-06-01
影响因子：
3
通讯作者：
Waterston, Robert H.
中科院分区：
文献类型：
--
作者：
Boyle, Thomas J.;Bao, Zhirong;Murray, John I.;Araya, Carlos L.;Waterston, Robert H.
秀丽隐杆线虫的不变谱系有潜力作为描述突变表型和基因表达模式的有力工具。我们先前描述了秀丽隐杆线虫胚胎细胞谱系的成像和自动提取程序。这种方法使用一种表达组蛋白-绿色荧光蛋白融合的菌株的延时共聚焦成像和一个软件包StarryNite，处理数千张图像并产生输出文件，描述每个时间点每个细胞核的位置和谱系关系。我们已经开发了一个配套软件包，AceTree，它使用谱系的树表示将图像和注释连接起来。这促进了谱系的管理和编辑。AceTree还包含强大的可视化和解释工具，如空间填充模型和基于树的表达模式，可用于从数据中提取生物学意义。通过将用C编写的快速线性化程序与用Java编写的用户界面程序配对，我们已经生成了一个用于探索胚胎发育的强大软件套件。
The invariant lineage of the nematode Caenorhabditis elegans has potential as a powerful tool for the description of mutant phenotypes and gene expression patterns. We previously described procedures for the imaging and automatic extraction of the cell lineage from C. elegans embryos. That method uses time-lapse confocal imaging of a strain expressing histone-GFP fusions and a software package, StarryNite, processes the thousands of images and produces output files that describe the location and lineage relationship of each nucleus at each time point. We have developed a companion software package, AceTree, which links the images and the annotations using tree representations of the lineage. This facilitates curation and editing of the lineage. AceTree also contains powerful visualization and interpretive tools, such as space filling models and tree-based expression patterning, that can be used to extract biological significance from the data. By pairing a fast lineaging program written in C with a user interface program written in Java we have produced a powerful software suite for exploring embryonic development.
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影响因子：
2.7
作者：
Schnabel, R;Hutter, H;Schnabel, H
通讯作者：
Schnabel, H
影响因子：
2.7
作者：
SULSTON, JE;SCHIERENBERG, E;THOMSON, JN
通讯作者：
THOMSON, JN
DOI：
10.1073/pnas.0511111103
发表时间：
2006-02-21
影响因子：
11.1
作者：
Bao, ZR;Murray, JI;Waterston, RH
通讯作者：
Waterston, RH
影响因子：
2.7
作者：
Azzaria, M;Goszczynski, B;McGhee, JD
通讯作者：
McGhee, JD
影响因子：
5.8
作者：
Saldanha, AJ
通讯作者：
Saldanha, AJ