Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice.
Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice.
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使用噬菌体 JD007 预防裸鼠金黄色葡萄球菌引起的真皮脓肿形成
DOI：
10.3389/fmicb.2018.01553
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发表时间：
2018
影响因子：
5.2
通讯作者：
Cui Z
中科院分区：
文献类型：
--
作者：
Ding B;Li Q;Guo M;Dong K;Zhang Y;Guo X;Liu Q;Li L;Cui Z
目的：在这项研究中，葡萄球菌噬菌体JD 007杀菌活性和诱导的免疫反应在治疗过程中进行了评估，在皮肤脓肿模型。材料和方法：用临床分离的沙门氏菌建立裸鼠皮肤脓肿模型。金黄色葡萄球菌SA325分离自背部皮下脓肿的住院病人。结果：噬菌体JD 007能抑制S.金黄色葡萄球菌SA325在MOI = 1或10下，显著防止皮肤肿胀的形成。通过细胞因子检测，预防组观察到中等免疫应答。结论：噬菌体JD 007可抑制临床沙门氏菌引起的皮肤肿胀的形成。金黄色葡萄球菌菌株在裸鼠中没有强烈的免疫应答。
Aim: In this study, Staphylococcus phage JD007 bactericidal activity and induced immune responses during treatment were assessed in a dermal abscess model. Materials and Methods: Dermal abscesses in nude mice were established by injecting a clinical isolate of S. aureus SA325 isolated from the back under-dermal abscess of an in-patient. Results: Phage JD007 was able to inhibit the growth of S. aureus SA325 at MOI = 1 or 10, significantly preventing the formation of dermal abscesses. Moderate immune responses were observed in the prevention group through detection of cytokines. Conclusion: Phage JD007 inhibits the formation of dermal abscesses caused by a clinical S. aureus strain in nude mice without robust immune responses.
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影响因子：
3.7
作者：
Andrew AS;Hu T;Gu J;Gui J;Ye Y;Marsit CJ;Kelsey KT;Schned AR;Tanyos SA;Pendleton EM;Mason RA;Morlock EV;Zens MS;Li Z;Moore JH;Wu X;Karagas MR
通讯作者：
Karagas MR
影响因子：
3.7
作者：
Chhibber S;Kaur T;Sandeep Kaur
通讯作者：
Sandeep Kaur
DOI：
10.1007/978-1-62703-481-4_14
发表时间：
2013-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Malachowa, Natalia;Kobayashi, Scott D;DeLeo, Frank R
通讯作者：
DeLeo, Frank R
影响因子：
2.8
作者：
Kumari, Seema;Harjai, Kusum;Chhibber, Sanjay
通讯作者：
Chhibber, Sanjay
影响因子：
4.9
作者：
Capparelli, Rosanna;Parlato, Marianna;Iannelli, Domenico
通讯作者：
Iannelli, Domenico