The development and course of bipolar spectrum disorders: an integrated reward and circadian rhythm dysregulation model.
The development and course of bipolar spectrum disorders: an integrated reward and circadian rhythm dysregulation model.
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DOI：
10.1146/annurev-clinpsy-032814-112902
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发表时间：
2015
影响因子：
18.4
通讯作者：
Boland EM
中科院分区：
文献类型：
--
作者：
Alloy LB;Nusslock R;Boland EM
在这篇文章中，我们提出并回顾了两种主要的双相情感障碍（bsd）发病和病程的生物心理社会理论的证据，这些理论整合了行为、环境和神经生物学机制：奖励超敏感和社会和昼夜节律中断模型。我们描述了bsd的临床特征、频谱、发病年龄和病程。然后，我们讨论了相关的研究设计，以证明假设的机制是否代表了bsd病程的相关性、脆弱性或预测因素，以及重要的方法问题。接下来，我们提出了BSD的奖励超敏模型，然后是BSD的社会/昼夜节律中断模型。对于每个模型，我们回顾了所提出的潜在机制是否与bsd相关的证据，为bsd的发作提供了脆弱性，并预测了bsd的病程。然后，我们提出了一个新的BSD的综合奖励/昼夜节律（RCR）失调模型，并讨论了RCR模型如何解释BSD的症状、发病和病程。最后对未来的研究方向提出了建议。
In this article, we present and review the evidence for two major biopsychosocial theories of the onset and course of bipolar spectrum disorders (BSDs) that integrate behavioral, environmental, and neurobiological mechanisms: the reward hypersensitivity and the social and circadian rhythm disruption models. We describe the clinical features, spectrum, age of onset, and course of BSDs. We then discuss research designs relevant to demonstrating whether a hypothesized mechanism represents a correlate, vulnerability, or predictor of the course of BSDs, as well as important methodological issues. We next present the reward hypersensitivity model of BSD, followed by the social/circadian rhythm disruption model of BSD. For each model, we review evidence regarding whether the proposed underlying mechanism is associated with BSDs, provides vulnerability to the onset of BSDs, and predicts the course of BSDs. We then present a new integrated reward/circadian rhythm (RCR) dysregulation model of BSD and discuss how the RCR model explains the symptoms, onset, and course of BSDs. We end with recommendations for future research directions.
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影响因子：
4.8
作者：
Albrecht U
通讯作者：
Albrecht U
沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。
影响因子：
4.6
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
通讯作者：
Hogan M
影响因子：
4.8
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Nusslock, Robin
通讯作者：
Nusslock, Robin
影响因子：
2.5
作者：
Benedetti, F.;Radaelli, D.;Smeraldi, E.
通讯作者：
Smeraldi, E.
影响因子：
5.4
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Hogan, Michael E.
通讯作者：
Hogan, Michael E.