Orbitofrontal cortex volume and brain reward response in obesity.
Orbitofrontal cortex volume and brain reward response in obesity.
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DOI：
10.1038/ijo.2014.121
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发表时间：
2015-02
影响因子：
4.9
通讯作者：
Frank, G. K. W.
中科院分区：
文献类型：
--
作者：
Shott, M. E.;Cornier, M-A;Mittal, V. A.;Pryor, T. L.;Orr, J. M.;Brown, M. S.;Frank, G. K. W.
人们对导致食物过度消费的原因知之甚少。大脑结构和功能的改变可能有助于增加食物寻求。近年来，研究者们发现大脑眶额皮质的体积与饮食失调有关，但对大脑结构与功能的关系知之甚少。我们使用多模式脑成像方法检查了肥胖女性（n=18，年龄=28.7.4±8.3岁）和健康对照女性（n=24，年龄=27.4±6.3岁）。我们应用磁共振和弥散张量成像研究大脑灰质和白色物质体积以及白色物质完整性，并测试眶额皮质体积是否预测大脑奖赏回路激活的味觉记忆-学习范式，已与多巴胺功能。与对照组相比，肥胖个体的眶额皮质、纹状体和脑岛的灰色物质和相关的白色物质体积较低（p<0.05家族误差（FWE）-小体积校正）。肥胖个体的白色物质完整性在包括外囊、放射冠、矢状层和钩椎、下额枕和下纵束在内的纤维束中减少。在对照组中，眶额皮质内侧边缘的直回灰质体积可预测额叶皮质、杏仁核、基底神经节、杏仁核、下丘脑和前扣带回皮质的功能性味觉奖励学习反应，但在肥胖组中则不然。这项研究表明，内侧眶额皮质体积和味觉记忆-学习激活之间有很强的关联，在控制组中，而在肥胖组中则没有。眶额皮质和其他与味觉奖赏功能相关的大脑区域的脑容量较低，以及肥胖症患者连接通路的完整性较低，可能支持奖赏通路更广泛的中断。内侧眶额皮质是终止食物摄入的重要结构，该结构和相关结构的干扰可能导致肥胖症患者过度食用食物。
What drives overconsumption of food is poorly understood. Alterations in brain structure and function could contribute to increased food seeking. Recently brain orbitofrontal cortex volume has been implicated in dysregulated eating but little is know how brain structure relates to function. We examined obese (n=18, age=28.7.4±8.3 years) and healthy control women (n=24, age=27.4±6.3 years) using a multimodal brain imaging approach. We applied magnetic resonance and diffusion tensor imaging to study brain gray and white matter volume as well as white matter integrity, and tested whether orbitofrontal cortex volume predicts brain reward circuitry activation in a taste reinforcement-learning paradigm that has been associated with dopamine function. Obese individuals displayed lower gray and associated white matter volumes (p<.05 family wise error (FWE)-small volume corrected) compared to controls in the orbitofrontal cortex, striatum, and insula. White matter integrity was reduced in obese individuals in fiber tracts including the external capsule, corona radiata, sagittal stratum, and the uncinate, inferior fronto-occipital, and inferior longitudinal fasciculi. Gray matter volume of the gyrus rectus at the medial edge of the orbitofrontal cortex predicted functional taste reward-learning response in frontal cortex, insula, basal ganglia, amygdala, hypothalamus and anterior cingulate cortex in control but not obese individuals. This study indicates a strong association between medial orbitofrontal cortex volume and taste reinforcement-learning activation in the brain in control but not in obese women. Lower brain volumes in the orbitofrontal cortex and other brain regions associated with taste reward function as well as lower integrity of connecting pathways in obesity may support a more widespread disruption of reward pathways. The medial orbitofrontal cortex is an important structure in the termination of food intake and disturbances in this and related structures could contribute to overconsumption of food in obesity.
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影响因子：
3.5
作者：
Cerf-Ducastel, B;Ven de Moortele, PF;Faurion, A
通讯作者：
Faurion, A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.3
作者：
Kazlouski, Demitry;Rollin, Michael D. H.;Tregellas, Jason;Shott, Megan E.;Jappe, Leah M.;Hagman, Jennifer O.;Pryor, Tamara;Yang, Tony T.;Frank, Guido K. W.
通讯作者：
Frank, Guido K. W.
影响因子：
4.8
作者：
Hao, Xuejun;Xu, Dongrong;Bansal, Ravi;Dong, Zhengchao;Liu, Jun;Wang, Zhishun;Kangarlu, Alayar;Liu, Feng;Duan, Yunsuo;Shova, Satie;Gerber, Andrew J.;Peterson, Bradley S.
通讯作者：
Peterson, Bradley S.
影响因子：
3.7
作者：
London, ED;Ernst, M;Weinstein, A
通讯作者：
Weinstein, A