Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance.
Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance.
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DOI：
10.1016/j.pscychresns.2010.12.006
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发表时间：
2011-05-31
影响因子：
2.3
通讯作者：
Frank, Guido K. W.
中科院分区：
文献类型：
--
作者：
Kazlouski, Demitry;Rollin, Michael D. H.;Tregellas, Jason;Shott, Megan E.;Jappe, Leah M.;Hagman, Jennifer O.;Pryor, Tamara;Yang, Tony T.;Frank, Guido K. W.
神经性厌食症（AN）与高度焦虑有关。驱动这些行为的大脑机制尚不清楚。在这项研究中，我们想测试AN是否改变了脑WM完整性，并与焦虑加剧有关。16名成年AN女性（平均年龄24±7岁）和17名健康对照女性（CW，平均年龄25±4岁）接受脑弥散张量成像（DTI）检查。利用DTI脑图像计算脑脊髓束的分数各向异性（FA），这是衡量脑脊髓束完整性的一个指标。a组与CW组相比，双侧穹窿毡、额枕束和后扣带WM的FA明显减少（p<0.05，校正）。AN组通过左侧（F=5.8, Beta= - 0.54, p<0.03）和右侧（F=6.0, Beta= - 0.55, p<0.03）穹窿膜FA预测伤害规避。这些发现不是由于AN的WM体积缺陷。本研究表明，神经网络边缘和关联通路的WM完整性异常，可能导致神经网络摄食、情绪加工和身体感知障碍。通过穹窿纤维-脑膜完整性预测AN的伤害避免表明，这一途径可能在机制上参与AN的高焦虑。
The eating disorder anorexia nervosa (AN) is associated with high anxiety. The brain mechanisms that drive those behaviors are unknown. In this study we wanted to test whether brain WM integrity is altered in AN, and related to heightened anxiety. Sixteen adult women with AN (mean age 24±7 years) and 17 healthy control women (CW, mean age 25±4 years) underwent diffusion tensor imaging (DTI) of the brain. The DTI brain images were used to calculate the fractional anisotropy (FA) of WM tracts, which is a measure for WM integrity. AN individuals compared to CW showed clusters of significantly reduced FA (p<0.05, corrected) in the bilateral fimbria-fornix, fronto-occipital fasciculus, as well as posterior cingulum WM. In the AN group, Harm Avoidance was predicted by left (F=5.8, Beta=−0.54, p<0.03) and right (F=6.0, Beta=−0.55, p<0.03) fimbria-fornix FA. Those findings were not due to WM volume deficits in AN. This study indicates that WM integrity is abnormal in AN in limbic and association pathways, which could contribute to disturbed feeding, emotion processing and body perception in AN. The prediction of Harm Avoidance in AN by fimbria-fornix WM integrity suggests that this pathway may be mechanistically involved in high anxiety in AN.
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影响因子：
5.7
作者：
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通讯作者：
Thompson PM
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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