Assessment of Nicotine and Cannabis Vaping and Respiratory Symptoms in Young Adults.
Assessment of Nicotine and Cannabis Vaping and Respiratory Symptoms in Young Adults.
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DOI：
10.1001/jamanetworkopen.2020.30189
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发表时间：
2020-12-01
影响因子：
13.8
通讯作者：
McConnell R
中科院分区：
文献类型：
--
作者：
Braymiller JL;Barrington-Trimis JL;Leventhal AM;Islam T;Kechter A;Krueger EA;Cho J;Lanza I;Unger JB;McConnell R
这项横断面研究探讨了尼古丁vaping和大麻vaping是否与年轻人的支气管炎症状，喘息和呼吸急促有关。尼古丁和大麻vaping与年轻人的呼吸短促，喘息和支气管炎症状有关吗？在这项对2553名年轻人的横断面研究中，任何水平的大麻vaping都与支气管炎症状的几率增加有关，上个月大麻vaping 3次或更多次与喘息的几率增加有关，即使在同时调整尼古丁vaping，吸烟和可燃大麻使用之后。大麻vaping可能与年轻人的支气管炎症状有关，超出了具有共同风险途径的其他药物使用行为的后果。电子烟（即尼古丁vaping）和大麻vaping的使用率在青年和年轻人中继续增加。然而，尼古丁和大麻vaping与独立的呼吸系统健康结果的关联尚未得到很好的研究。研究尼古丁和大麻电子烟与支气管炎症状、喘息和呼吸短促的关系。从2018年6月至2019年10月收集了从南加州高中招募的2553名年轻人自我报告的生命周期，6个月和30天电子烟的横断面调查数据。在这些参与者中，94%提供了呼吸短促和喘息的数据，86%提供了慢性支气管炎的数据。使用以下回答在Likert类型量表上测量自我报告的尼古丁和大麻vaping：（1）从未使用过，（2）终身但过去6个月未使用，（3）过去6个月使用但过去30天未使用，（4）过去30天中的1或2天使用，以及（5）过去30天中的3天或更多天使用。根据自我报告的症状，分别评估了三种呼吸系统健康结局：过去12个月的支气管炎症状（即连续3个月每日咳嗽，充血或痰，而不是感冒和/或支气管炎），过去12个月的喘息，以及在平地上匆忙或走上小山坡时呼吸急促。在分析样本中的2553名参与者（平均[SD]年龄，19.3 [0.79]岁; 1477名[57.9%]女性）中，2553名年轻人中有1095名（42.9%）报告了尼古丁，2553名中有939名（38.4%）报告了大麻。与从未吸食大麻的人相比，在过去60个月内吸食大麻的人（204/2553 [8.4%];调整后比值比[aOR]，1.83 [95% CI，1.08-3.10]），在过去6个月内，但在过去30天内未发生（490/2443 [20.1%]; aOR，1.58 [95% CI，1.02-2.46]），过去30天内1-2天（90/2443 [3.7%]; aOR，2.83 [95%CI，1.46-5.50]），过去30天内≥ 3天（155/2443 [6.3%]; aOR，2.14 [95%CI，1.16-3.92]）在调整尼古丁蒸汽、吸烟、大麻吸烟和社会人口学特征后，慢性支气管炎症状的几率显著较高。在过去30天内吸食大麻3次或更多次也与喘息的几率增加有关（aOR，2.27 [95% CI，1.17-4.37]）。在完全调整的模型中，大麻vaping与呼吸急促和尼古丁vaping与任何呼吸健康结果的关联没有统计学意义。这项横断面研究的结果表明，大麻vaping与年轻人支气管炎症状和喘息的风险增加有关。需要进一步的研究来了解这种关联的暂时性以及尼古丁和大麻vaping在支气管炎症状和喘息风险方面差异的机制。
This cross-sectional study examines whether nicotine vaping and cannabis vaping are associated with bronchitic symptoms, wheeze, and shortness of breath in young adults. Are nicotine and cannabis vaping associated with shortness of breath, wheeze, and bronchitic symptoms in young adults? In this cross-sectional study of 2553 young adults, cannabis vaping at any level was associated with increased odds of bronchitic symptoms, and cannabis vaping 3 or more times in the last month was associated with increased odds of wheeze, even after simultaneously adjusting for nicotine vaping, cigarette smoking, and combustible cannabis use. Cannabis vaping may be associated with bronchitic symptoms in young adults, beyond the consequences of other drug use behaviors with shared risk pathways. Rates of e-cigarette use (ie, nicotine vaping) and cannabis vaping continue to increase among youth and young adults. However, the association of nicotine and cannabis vaping with independent respiratory health outcomes has not been well studied. To investigate associations of nicotine and cannabis vaping with bronchitic symptoms, wheeze, and shortness of breath. Cross-sectional survey data on self-reported lifetime, 6-month, and 30-day vaping from 2553 young adults recruited from high schools in Southern California were collected from June 2018 to October 2019. Of these participants, 94% provided data for shortness of breath and wheeze, and 86% provided data for chronic bronchitis. Self-reported nicotine and cannabis vaping were measured on a Likert-type scale using the following responses: (1) never used, (2) lifetime but no past 6-month use, (3) past 6-month use but no use in the past 30 days, (4) use on 1 or 2 of the past 30 days, and (5) use on 3 or more of the past 30 days. Three respiratory health outcomes were assessed separately on the basis of self-reported symptoms: bronchitic symptoms in the previous 12 months (ie, daily cough for 3 months in a row, congestion or phlegm other than with a cold, and/or bronchitis), wheeze in the previous 12 months, and shortness of breath when hurrying on level ground or walking up a slight hill. Of 2553 participants in the analytic sample (mean [SD] age, 19.3 [0.79] years; 1477 [57.9%] female individuals), 1095 of 2553 young adults (42.9%) reported vaping nicotine and 939 of 2553 (38.4%) reported vaping cannabis. Compared with those who never vaped cannabis, individuals who vaped cannabis in their lifetime but not in the past 60 months (204 of 2553 [8.4%]; adjusted odds ratio [aOR], 1.83 [95% CI, 1.08-3.10]), in the past 6 months but not in the last 30 days (490 of 2443 [20.1%]; aOR, 1.58 [95% CI, 1.02-2.46]), 1-2 days in the past 30 days (90 of 2443 [3.7%]; aOR, 2.83 [95% CI, 1.46-5.50]), and 3 or more days in the past 30 days (155 of 2443 [6.3%]; aOR, 2.14 [95% CI, 1.16-3.92]) had significantly higher odds of chronic bronchitic symptoms after adjusting for nicotine vaping, cigarette smoking, cannabis smoking, and sociodemographic characteristics. Cannabis vaping 3 or more times in the last 30 days was also associated with increased odds of wheeze (aOR, 2.27 [95% CI, 1.17-4.37]). Associations of cannabis vaping with shortness of breath and nicotine vaping with any respiratory health outcome were not statistically significant in fully adjusted models. Findings of this cross-sectional study suggest that cannabis vaping is associated with increased risk of bronchitic symptoms and wheeze in young adults. Further research is needed to understand the temporality of the association and the mechanisms underlying the difference between nicotine and cannabis vaping in the risk of bronchitic symptoms and wheeze.
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DOI：
10.1001/jama.2015.8950
发表时间：
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期刊：
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影响因子：
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通讯作者：
McConnell R