The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.
The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.
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伤口因素以及疲劳和疼痛症状与慢性静脉性腿部溃疡伤口愈合的关系。
DOI：
10.1111/iwj.13966
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发表时间：
2023-04
影响因子：
3.1
通讯作者：
Lyon, Debra E.
中科院分区：
文献类型：
--
作者：
Kim, Junglyun;Stechmiller, Joyce;Weaver, Michael;Gibson, Daniel J.;Horgas, Ann;Kelly, Debra L.;Lyon, Debra E.
本研究的目的是：（1）确定慢性下肢静脉溃疡（CVLU）患者随时间推移的伤口面积、伤口渗出液C反应蛋白（CRP）、广谱基质金属蛋白酶蛋白（MMPs）以及疲劳和疼痛症状之间的相关性;（2）确定与CVLU伤口愈合轨迹相关的因素。在8周研究期间，从伤口护理诊所招募了74名每周接受锐性清创的CVLU受试者。为了检查伤口CRP、MMPs、疼痛、疲劳和伤口愈合轨迹随时间的变化之间的关联，我们基于线性混合模型计算贝叶斯因子（BF）。基线时，参与者的平均年龄为71.8岁（SD = 9.8），平均伤口面积为2278 mm 2（SD = 7085 mm 2）。较高的疲劳与较高的MMPs（BF = 9，95%HDI：[-05，.43]）、较低的CRP（BF = 11，95%HDI：[-02，.002]）和大面积伤口（BF = 20，95%HDI：[-001，.01]）密切相关。伤口渗出液中CRP和MMPs活性较高以及疲劳程度较高与伤口面积较大相关。为了促进伤口愈合，临床医生需要利用多因素方法，其中包括伤口治疗和疼痛和疲劳等症状的管理，因为伤口愈合涉及分子和心理行为因素。
The purpose of this study was: (1) to characterise the association of wound area, wound exudate C‐reactive protein (CRP), broad‐spectrum matrix metalloprotease protein (MMPs), and symptoms of fatigue and pain in individuals with chronic venous leg ulcers (CVLUs) over time and (2) to identify factors associated with the wound healing trajectory in CVLUs. Seventy four participants with CVLU who received weekly sharp debridement were recruited from a wound care clinic during the 8‐week study period. To examine associations among wound CRP, MMPs, pain, fatigue, and wound healing trajectory over time, we calculated Bayes factors (BF) based on a linear mixed model. The mean age of participants was 71.8 (SD = 9.8) and the mean wound area was 2278 mm2 (SD = 7085 mm2) at baseline. Higher fatigue was strongly associated with higher MMPs (BF = 9, 95% HDI: [−.05, .43]), lower CRP (BF = 11, 95% HDI: [−.02, .002]), and large areas of wound (BF = 20, 95% HDI: [−.001, .01]). Higher CRP and MMPs activity in wound exudate and higher fatigue were associated with a larger wound area. To facilitate wound healing, clinicians need to utilise the multifactorial approach, which includes wound treatment and management of symptoms such as pain and fatigue, because of the molecular and psycho‐behavioural factors involved in wound healing.
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影响因子：
2.6
作者：
Goto, Taichi;Saligan, Leorey N.
通讯作者：
Saligan, Leorey N.
影响因子：
6.5
作者：
Bigliardi, PL;Sumanovski, LT;Bigliardi-Qi, M
通讯作者：
Bigliardi-Qi, M
影响因子：
3.5
作者：
Beekman, B;Drijfhout, JW;Koppele, JMT
通讯作者：
Koppele, JMT
影响因子：
3.1
作者：
Cresta Morgado, P.;Giorlando, A.;Navigante, A.
通讯作者：
Navigante, A.
DOI：
10.1016/j.jvsv.2014.08.002
发表时间：
2015-04-01
影响因子：
3.2
作者：
Ahmad, Anwar;Saha, Prakash;Smith, Alberto
通讯作者：
Smith, Alberto