Midlife aerobic exercise and brain structural integrity: Associations with age and cardiorespiratory fitness.
Midlife aerobic exercise and brain structural integrity: Associations with age and cardiorespiratory fitness.
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DOI：
10.1016/j.neuroimage.2020.117512
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发表时间：
2021-01-15
期刊：
影响因子：
5.7
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Tarumi T;Tomoto T;Repshas J;Wang C;Hynan LS;Cullum CM;Zhu DC;Zhang R
中年体力活动减少与晚年患神经退行性疾病的风险增加有关。然而，体育锻炼和健身是否与中年大脑结构完整性有关仍然是未知的。本研究的目的是比较经过有氧训练的中年成年人（MA）、中年久坐者（MS）和年轻久坐者（YS）的大脑结构。30名MA（54 ± 4岁）、30名MS（54 ± 4岁）和30名YS（32 ± 6岁）参与者（50%女性）使用MRI测量了脑体积皮质厚度和白色（WM）纤维完整性。MA参与者进行了24.8 ± 9.6年的有氧训练，最高的心肺健康水平（即，峰值摄氧量：VO2峰值）。与YS组相比，MS组的整体WM完整性（通过扩散张量成像的各向异性分数（FA）进行评估）较低。MA组总FA显著高于MS组（P <0.05），与YS组相近。此外，基于束的空间统计分析表明，前、上级和边缘WM束（例如，MA组胼胝体、上级纵束、钩束）的收缩率高于MS组，且与VO2峰值呈正相关，与年龄和性别无关。从皮质厚度分析MS和MA参与者显示薄的前额叶和顶颞区比YS组。在另一方面，MA组表现出较厚的中央前，中央后，carcarcarine，和外侧枕叶皮质比MS和YS组。但是，MA组的右侧和右侧上级额上回的皮质厚度较MS组薄。总的来说，这些研究结果表明，中年有氧运动与更高的WM完整性和更大的初级运动和体感皮层厚度。
Lower midlife physical activity is associated with higher risk of neurodegenerative disease in late life. However it remains unknown whether physical exercise and fitness are associated with brain structural integrity during midlife. The purpose of this study was to compare brain structures between middle-aged aerobically trained adults (MA), middle-aged sedentary (MS), and young sedentary (YS) adults. Thirty MA (54 ± 4 years), 30 MS (54 ± 4 years), and 30 YS (32 ± 6 years) participants (50% women) underwent measurements of brain volume cortical thickness, and white matter (WM) fiber integrity using MRI. MA participants had aerobic training for 24.8 ± 9.6 years and the highest cardiorespiratory fitness level (i.e., peak oxygen uptake: VO2peak) among all groups. Global WM integrity, as assessed with fractional anisotropy (FA) from diffusion tensor imaging, was lower in the MS compared with the YS group. However, global FA in the MA group was significantly higher than that in the MS group (P <0.05) and at a similar level to the YS group. Furthermore, tract-based spatial statistical analysis demonstrated that FA in the anterior, superior, and limbic WM tracts (e.g., the genu of the corpus callosum, superior longitudinal fasciculus, uncinate fasciculus) was higher in the MA compared with MS groups, and positively associated with VO2peak, independently from age and sex. From cortical thickness analysis MS and MA participants showed thinner prefrontal and parieto-temporal areas than the YS group. On the other hand, the MA group exhibited thicker precentral, postcentral, pericalcarine, and lateral occipital cortices than the MS and YS groups. But, the insula and right superior frontal gyrus showed thinner cortical thickness in the MA compared with the MS groups. Collectively, these findings suggest that midlife aerobic exercise is associated with higher WM integrity and greater primary motor and somatosensory cortical thickness.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
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影响因子：
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