A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals.
A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals.
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DOI：
10.1186/s40658-022-00456-0
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发表时间：
2022-04-13
期刊：
影响因子：
4
通讯作者：
Bolch WE
中科院分区：
文献类型：
--
作者：
Correa-Alfonso CM;Withrow JD;Domal SJ;Xing S;Shin J;Grassberger C;Paganetti H;Bolch WE
建立成人肝脏内部血管模型，并证明其在区分肝实质内放射性药物衰变部位与器官血液内放射性药物衰变部位方面的应用。在ICRP成年女性和男性肝脏（AFL/AML）的各个叶内通过算法创建肝动脉（HA）、肝静脉（HV）和肝门静脉（HPV）血管树的计算机生成模型。对于算法的每次迭代，随着创建每条新血管并连接到可行分叉部位，更新每条树内的压力、血流和血管半径。然后将AFL/AML内创建的血管网络四面体化以耦合到PHITS辐射传输代码。计算了单能α粒子、电子、正电子和光子的特定吸收分数（SAF）。提出了AFL/AML的双区域肝脏模型，并假设两个位置内的血液中的放射性核素衰变计算颗粒特异性SAF值：（1）明确建模的肝血管内的部位，以及（2）位于这些血管外的肝血池内的部位，包括毛细血管和血窦。使用双区域肝脏模型分别计算了放射性药物治疗和成像中常用的22种和10种放射性核素的S值，并与现有单区域肝脏模型中获得的S值进行了比较。为ICRP参考创建了具有约6000个非交叉直圆柱体虚拟血管的肝脏模型，代表HA、HPV和HV循环。对于α发射体和β和俄歇电子发射体，使用单区域模型的S值分别比使用双区域模型获得的S值高约11%（AML）至14%（AFL）和11%（AML）至13%（AFL）。本研究中采用的方法表明，通过明确考虑α粒子（所有能量）和能量低于~ 100 keV的电子的血液自身剂量，器官实质剂量测定得到了改善。
To develop a model of the internal vasculature of the adult liver and demonstrate its application to the differentiation of radiopharmaceutical decay sites within liver parenchyma from those within organ blood. Computer-generated models of hepatic arterial (HA), hepatic venous (HV), and hepatic portal venous (HPV) vascular trees were algorithmically created within individual lobes of the ICRP adult female and male livers (AFL/AML). For each iteration of the algorithm, pressure, blood flow, and vessel radii within each tree were updated as each new vessel was created and connected to a viable bifurcation site. The vascular networks created inside the AFL/AML were then tetrahedralized for coupling to the PHITS radiation transport code. Specific absorbed fractions (SAF) were computed for monoenergetic alpha particles, electrons, positrons, and photons. Dual-region liver models of the AFL/AML were proposed, and particle-specific SAF values were computed assuming radionuclide decays in blood within two locations: (1) sites within explicitly modeled hepatic vessels, and (2) sites within the hepatic blood pool residing outside these vessels to include the capillaries and blood sinuses. S values for 22 and 10 radionuclides commonly used in radiopharmaceutical therapy and imaging, respectively, were computed using the dual-region liver models and compared to those obtained in the existing single-region liver model. Liver models with virtual vasculatures of ~ 6000 non-intersecting straight cylinders representing the HA, HPV, and HV circulations were created for the ICRP reference. For alpha emitters and for beta and auger-electron emitters, S values using the single-region models were approximately 11% (AML) to 14% (AFL) and 11% (AML) to 13% (AFL) higher than the S values obtained using the dual-region models, respectively. The methodology employed in this study has shown improvements in organ parenchymal dosimetry through explicit consideration of blood self-dose for alpha particles (all energies) and for electrons at energies below ~ 100 keV.
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DOI：
10.1085/jgp.9.6.835
发表时间：
1926-07-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Murray CD
通讯作者：
Murray CD
影响因子：
4.6
作者：
Debbaut, Charlotte;Monbaliu, Diethard;Segers, Patrick
通讯作者：
Segers, Patrick
影响因子：
--
作者：
Bolch, W E;Eckerman, K;Zankl, M
通讯作者：
Zankl, M
影响因子：
7.7
作者：
Karch, R;Neumann, F;Schreiner, W
通讯作者：
Schreiner, W
影响因子：
4.3
作者：
Eipel, Christian;Abshagen, Kerstin;Vollmar, Brigitte
通讯作者：
Vollmar, Brigitte