Novel Insights into Chromosome Evolution in Birds, Archosaurs, and Reptiles.
Novel Insights into Chromosome Evolution in Birds, Archosaurs, and Reptiles.
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DOI：
10.1093/gbe/evw166
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发表时间：
2016-08-25
影响因子：
3.3
通讯作者：
Larkin DM
中科院分区：
文献类型：
--
作者：
Farré M;Narayan J;Slavov GT;Damas J;Auvil L;Li C;Jarvis ED;Burt DW;Griffin DK;Larkin DM
哺乳动物染色体中的同源同线区（HSB）和进化断裂点区（EBRs）富含不同的DNA特征，导致不同的表型。为了揭示HSB和EBR在鸟类进化中的作用，我们使用最近测序的鸟类家族树基因组和新开发的算法对21种鸟类和5种外类群物种进行了基于序列的比较。我们在祖先鸟类、初龙类（鸟类、鳄鱼和恐龙）和爬行动物的染色体中鉴定了EBR和HSB。参与调控基因表达和生物合成过程的基因优选位于HSB中，包括例如富集参与肢体发育的基因的禽类特异性HSB。在鸟类中，一些谱系特异性的EBRs重排基因与不同的表型有关，例如鹦鹉的前脑发育。我们的研究结果为鸟类基因组进化提供了新的进化见解，特别是染色体重排可能如何促成新表型的形成。
Homologous synteny blocks (HSBs) and evolutionary breakpoint regions (EBRs) in mammalian chromosomes are enriched for distinct DNA features, contributing to distinct phenotypes. To reveal HSB and EBR roles in avian evolution, we performed a sequence-based comparison of 21 avian and 5 outgroup species using recently sequenced genomes across the avian family tree and a newly-developed algorithm. We identified EBRs and HSBs in ancestral bird, archosaurian (bird, crocodile, and dinosaur), and reptile chromosomes. Genes involved in the regulation of gene expression and biosynthetic processes were preferably located in HSBs, including for example, avian-specific HSBs enriched for genes involved in limb development. Within birds, some lineage-specific EBRs rearranged genes were related to distinct phenotypes, such as forebrain development in parrots. Our findings provide novel evolutionary insights into genome evolution in birds, particularly on how chromosome rearrangements likely contributed to the formation of novel phenotypes.
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影响因子：
12.3
作者：
Bailey JA;Baertsch R;Kent WJ;Haussler D;Eichler EE
通讯作者：
Eichler EE
DOI：
10.1126/science.1253451
发表时间：
2014-12-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jarvis ED;Mirarab S;Aberer AJ;Li B;Houde P;Li C;Ho SY;Faircloth BC;Nabholz B;Howard JT;Suh A;Weber CC;da Fonseca RR;Li J;Zhang F;Li H;Zhou L;Narula N;Liu L;Ganapathy G;Boussau B;Bayzid MS;Zavidovych V;Subramanian S;Gabaldón T;Capella-Gutiérrez S;Huerta-Cepas J;Rekepalli B;Munch K;Schierup M;Lindow B;Warren WC;Ray D;Green RE;Bruford MW;Zhan X;Dixon A;Li S;Li N;Huang Y;Derryberry EP;Bertelsen MF;Sheldon FH;Brumfield RT;Mello CV;Lovell PV;Wirthlin M;Schneider MP;Prosdocimi F;Samaniego JA;Vargas Velazquez AM;Alfaro-Núñez A;Campos PF;Petersen B;Sicheritz-Ponten T;Pas A;Bailey T;Scofield P;Bunce M;Lambert DM;Zhou Q;Perelman P;Driskell AC;Shapiro B;Xiong Z;Zeng Y;Liu S;Li Z;Liu B;Wu K;Xiao J;Yinqi X;Zheng Q;Zhang Y;Yang H;Wang J;Smeds L;Rheindt FE;Braun M;Fjeldsa J;Orlando L;Barker FK;Jønsson KA;Johnson W;Koepfli KP;O'Brien S;Haussler D;Ryder OA;Rahbek C;Willerslev E;Graves GR;Glenn TC;McCormack J;Burt D;Ellegren H;Alström P;Edwards SV;Stamatakis A;Mindell DP;Cracraft J;Braun EL;Warnow T;Jun W;Gilbert MT;Zhang G
通讯作者：
Zhang G
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
1.7
作者：
Griffin, D. K.;Robertson, L. B. W.;Skinner, B. M.
通讯作者：
Skinner, B. M.
影响因子：
56.9
作者：
Murphy, WJ;Larkin, DM;Lewin, HA
通讯作者：
Lewin, HA