A metering rotary nanopump for microfluidic systems.
A metering rotary nanopump for microfluidic systems.
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DOI：
10.1039/c0lc00087f
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发表时间：
2010-12-07
期刊：
影响因子：
6.1
通讯作者：
Seale KT
中科院分区：
文献类型：
--
作者：
Darby SG;Moore MR;Friedlander TA;Schaffer DK;Reiserer RS;Wikswo JP;Seale KT
我们描述了微制造计量旋转纳米泵的设计，制造和测试的目的，在微流体装置中驱动流体流动。微型蠕动泵由一组微流体通道组成，这些微流体通道围绕中心凸轮轴缠绕成螺旋状，非圆柱形凸轮在中心凸轮轴中旋转。凸轮在旋转时压缩螺旋通道以引起蠕动流。聚二甲基硅氧烷（PDMS）纳米泵设计能够产生间歇输送或每转几纳升流体的去除，以及从低至15 nL/min到1.0 µL/min以上的一致连续流速。在典型微流体设备中遇到的背压下，泵作为高阻抗流源。耐久性、生物相容性、与软光刻制造的集成的容易性、使用简单的旋转马达而不是多个同步的气动或机械致动器、以及在静止状态下不存在功耗或流体传导性，所有这些都有助于具有低制造成本和通用实施方式的紧凑泵。这表明泵设计可用于各种生物实验和床旁设备。
We describe the design, fabrication, and testing of a microfabricated metering rotary nanopump for the purpose of driving fluid flow in microfluidic devices. The miniature peristaltic pump is composed of a set of microfluidic channels wrapped in a helix around a central cam shaft in which a non-cylindrical cam rotates. The cam compresses the helical channels to induce peristaltic flow as it is rotated. The polydimethylsiloxane (PDMS) nanopump design is able to produce intermittent delivery or removal of several nanoliters of fluid per revolution as well as consistent continuous flow rates ranging from as low as 15 nL/min to above 1.0 µL/min. At back pressures encountered in typical microfluidic devices, the pump acts as a high impedance flow source. The durability, biocompatibility, ease of integration with soft-lithographic fabrication, the use of a simple rotary motor instead of multiple synchronized pneumatic or mechanical actuators, and the absence of power consumption or fluidic conductance in the resting state all contribute to a compact pump with a low cost of fabrication and versatile implementation. This suggests that the pump design may be useful for a wide variety of biological experiments and point of care devices.
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影响因子：
6.1
作者：
Faley S;Seale K;Hughey J;Schaffer DK;VanCompernolle S;McKinney B;Baudenbacher F;Unutmaz D;Wikswo JP
通讯作者：
Wikswo JP
影响因子：
56.9
作者：
Unger, MA;Chou, HP;Quake, SR
通讯作者：
Quake, SR
影响因子：
4.2
作者：
Studer, V;Pépin, A;Ajdari, A
通讯作者：
Ajdari, A
影响因子：
6.1
作者：
Werdich, AA;Lima, EA;Baudenbacher, FJ
通讯作者：
Baudenbacher, FJ
DOI：
10.1073/pnas.0404353101
发表时间：
2004-11-09
影响因子：
11.1
作者：
Gu, W;Zhu, XY;Takayama, S
通讯作者：
Takayama, S