Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD.
Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD.
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DOI：
10.1088/0031-9155/59/24/7819
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发表时间：
2014-12-21
影响因子：
3.5
通讯作者：
Lang T
中科院分区：
文献类型：
--
作者：
Bonaretti S;Carpenter RD;Saeed I;Burghardt AJ;Yu L;Bruesewitz M;Khosla S;Lang T
定量计算机断层扫描（QCT）越来越多地用于骨质疏松症研究，以评估体积骨矿物质密度（vBMD），骨质量和强度。然而，QCT在临床研究环境中面临着技术问题，例如身体大小对vBMD测量的潜在混杂影响以及缺乏标准的扫描仪交叉校准方法，这影响了多中心环境中vBMD的测量。在这项研究中，我们解决了系统的扫描仪间的差异和受试者依赖的身体尺寸误差使用一种新的拟人髋关节体模，包含一个校准髋关节估计校正方程，和对侧测试髋关节，以评估校正的质量。我们在四种不同的扫描仪上扫描了这个模型，并对16名绝经后妇女在两种扫描仪上扫描的体内图像进行了模型校正。从体模研究中，我们发现vBMD在四台扫描仪中的三台中随着体模尺寸的增加而降低，并且扫描仪间的变化随着体模尺寸的增加而增加。在体内研究中，我们观察到扫描仪间校正降低了系统扫描仪间平均vBMD差异，但扫描仪间精度误差仍大于已知扫描仪内精度测量的预期。总之，当从QCT图像测量vBMD时，应考虑扫描仪间校正和体型影响。
Quantitative computed tomography (QCT) is increasingly used in osteoporosis studies to assess volumetric bone mineral density (vBMD), bone quality and strength. However, QCT is confronted by technical issues in the clinical research setting, such as potentially confounding effects of body size on vBMD measurements and lack of standard approaches to scanner cross-calibration, which affects measurements of vBMD in multicenter settings. In this study, we addressed systematic inter-scanner differences and subject-dependent body size errors using a novel anthropomorphic hip phantom, containing a calibration hip to estimate correction equations, and a contralateral test hip to assess the quality of the correction. We scanned this phantom on four different scanners and we applied phantom-derived corrections to in-vivo images of 16 postmenopausal women scanned on two scanners. From the phantom study, we found that vBMD decreased with increasing phantom size in three of four scanners and that inter-scanner variations increased with increasing phantom size. In the in vivo study, we observed that inter-scanner corrections reduced systematic inter-scanner mean vBMD differences but that the inter-scanner precision error was still larger than expected from known intra-scanner precision measurements. In conclusion, inter-scanner corrections and body size influence should be considered when measuring vBMD from QCT images.
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影响因子：
1.9
作者：
Lang, Thomas F.
通讯作者：
Lang, Thomas F.
影响因子：
5
作者：
LEVI, C;GRAY, JE;HATTERY, RR
通讯作者：
HATTERY, RR
影响因子：
2.2
作者：
Carpenter, R. Dana;Saeed, Isra;Lang, Thomas F.
通讯作者：
Lang, Thomas F.
DOI：
10.1016/0169-6009(92)90922-z
发表时间：
1992-11-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
GOODSITT, MM
通讯作者：
GOODSITT, MM
影响因子：
4.1
作者：
Lang, TF;Keyak, JH;Genant, HK
通讯作者：
Genant, HK