Detection of Peripheral Arterial Disease Within the Foot Using Vascular Optical Tomographic Imaging: A Clinical Pilot Study.
Detection of Peripheral Arterial Disease Within the Foot Using Vascular Optical Tomographic Imaging: A Clinical Pilot Study.
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DOI：
10.1016/j.ejvs.2014.10.010
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发表时间：
2015-01
影响因子：
5.7
通讯作者：
Hielscher, A. H.
中科院分区：
文献类型：
--
作者：
Khalil, M. A.;Kim, H. K.;Hoi, J. W.;Kim, I.;Dayal, R.;Shrikhande, G.;Hielscher, A. H.
血管光学断层成像（VOTI）是一种新型的成像模式，能够检测组织中的血红蛋白浓度。VOTI是非侵入性的，非电离的，不需要注射造影剂。我们应用这项技术诊断下肢动脉钙化的糖尿病患者的外周动脉疾病（PAD）。由于这些患者患有动脉不可压缩性等合并症，这可能会带来实质性益处，这使得诊断和监测变得复杂。40名受试者（10名非糖尿病PAD患者，10名糖尿病PAD患者和20名健康志愿者）入组使用VOTI系统的诊断性初步研究。在大腿压力袖带闭塞期间对患者进行成像。VOTI系统能够量化大腿袖带闭塞期间足部内的血容量变化，并输出诊断参数，例如血红蛋白浓度的变化，从而能够评估足部灌注。该研究导致健康队列与非糖尿病和糖尿病PAD队列之间存在统计学显著差异（P=0.006，P=0.006）。受试者工作特征（ROC）曲线分析表明，PAD诊断的敏感性或特异性可超过80%，这取决于特征截断点。此外，VOTI能够提供足部灌注不足区域的位置，并评估动脉疾病的严重程度，即使是在传统上难以诊断的动脉钙化的糖尿病患者中。VOTI可以独立于动脉可压缩性有效地诊断PAD，这使得它对于评估糖尿病患者的血管疾病非常有用。
Vascular optical tomographic imaging (VOTI) is a novel imaging modality that is capable of detecting hemoglobin concentrations in tissue. VOTI is non-invasive, non-ionizing and does not require contrast injection. We applied this technology to diagnosing peripheral arterial disease (PAD) within lower extremities of diabetic patients with calcified arteries. This could be of substantial benefit as these patients suffer from comorbidities such as arterial incompressibility, which complicates diagnosis and monitoring. Forty subjects (10 non-diabetic patients with PAD, 10 diabetic patients with PAD, and 20 healthy volunteers) were enrolled in a diagnostic pilot study using the VOTI system. The patients were imaged during a thigh pressure cuff occlusion. The VOTI system was capable of quantifying the blood volume changes within the foot during the thigh cuff occlusion and outputting diagnostic parameters, such as change in hemoglobin concentration, enabling the assessment of foot perfusion. This study resulted in a statistically significant difference between the healthy cohort and both the non-diabetic and the diabetic PAD cohorts (P=0.006, P=0.006). Receiver operating characteristic (ROC) curve analysis showed that PAD diagnosis could be made with over 80% sensitivity or specificity depending on the characteristic cut-off point. In addition, VOTI was capable of providing the locations of under-perfused regions within the foot and evaluating the severity of arterial disease, even within diabetic patients with calcified arteries, which are traditionally difficult to diagnose. VOTI can effectively diagnose PAD independently of arterial compressibility, making it very useful for assessing vascular disease in diabetic patients.
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影响因子：
--
作者：
Hielscher AH;Bluestone AY;Abdoulaev GS;Klose AD;Lasker J;Stewart M;Netz U;Beuthan J
通讯作者：
Beuthan J
DOI：
10.1016/0007-1226(92)90081-8
发表时间：
1992-04-01
期刊：
BRITISH JOURNAL OF PLASTIC SURGERY
影响因子：
--
作者：
MCGREGOR, AD
通讯作者：
MCGREGOR, AD
影响因子：
3.8
作者：
Pogue, Brian W.;Testorf, Markus;Paulsen, Keith
通讯作者：
Paulsen, Keith
DOI：
10.1024/0301-1526.35.2.86
发表时间：
2006-05-01
期刊：
VASA-JOURNAL OF VASCULAR DISEASES
影响因子：
--
作者：
Krnic, A.;Vucic, N.;Sucic, Z.
通讯作者：
Sucic, Z.
影响因子：
10.6
作者：
Ntziachristos, V;Hielscher, AH;Chance, B
通讯作者：
Chance, B