Near-infrared diffuse optical tomography.
Near-infrared diffuse optical tomography.
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DOI:
10.1155/2002/164252
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发表时间:
2002
期刊:
影响因子:
--
通讯作者:
Beuthan J
中科院分区:
文献类型:
--
作者:
Hielscher AH;Bluestone AY;Abdoulaev GS;Klose AD;Lasker J;Stewart M;Netz U;Beuthan J
Diffuse optical tomography (DOT) is emerging as a viable new biomedical imaging modality. Using near-infrared (NIR) light, this technique probes absorption as well as scattering properties of biological tissues. First commercial instruments are now available that allow users to obtain cross-sectional and volumetric views of various body parts. Currently, the main applications are brain, breast, limb, joint, and fluorescence/bioluminescence imaging. Although the spatial resolution is limited when compared with other imaging modalities, such as magnetic resonance imaging (MRI) or X-ray computerized tomography (CT), DOT provides access to a variety of physiological parameters that otherwise are not accessible, including sub-second imaging of hemodynamics and other fast-changing processes. Furthermore, DOT can be realized in compact, portable instrumentation that allows for bedside monitoring at relatively low cost. In this paper, we present an overview of current state-of-the -art technology, including hardware and image-reconstruction algorithms, and focus on applications in brain and joint imaging. In addition, we present recent results of work on optical tomographic imaging in small animals.
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