Near-infrared diffuse optical tomography.

Near-infrared diffuse optical tomography.
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DOI:
10.1155/2002/164252
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发表时间:
2002
期刊:
影响因子:
--
通讯作者:
Beuthan J
Beuthan J
中科院分区:
医学4区
文献类型:
--
作者:
Hielscher AH;Bluestone AY;Abdoulaev GS;Klose AD;Lasker J;Stewart M;Netz U;Beuthan J

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扩散光学层析成像(DOT)正在成为一种可行的新的生物医学成像模式。使用近红外(NIR)光,该技术探测生物组织的吸收和散射特性。第一个商业仪器,现在可以让用户获得横截面和体积视图的各种身体部位。目前,主要的应用是脑、乳腺、肢体、关节和荧光/生物发光成像。虽然与其他成像方式(如磁共振成像(MRI)或X射线计算机断层扫描(CT))相比,空间分辨率有限,但DOT提供了对各种生理参数的访问,这些参数是无法访问的,包括血液动力学和其他快速变化过程的亚秒成像。此外,DOT可以在紧凑的便携式仪器中实现,其允许以相对低的成本进行床边监测。在本文中,我们提出了一个概述,目前国家的最先进的技术,包括硬件和图像重建算法,并专注于在大脑和关节成像的应用。此外,我们目前的工作在小动物的光学断层成像的最新成果。
Diffuse optical tomography (DOT) is emerging as a viable new biomedical imaging modality. Using near-infrared (NIR) light, this technique probes absorption as well as scattering properties of biological tissues. First commercial instruments are now available that allow users to obtain cross-sectional and volumetric views of various body parts. Currently, the main applications are brain, breast, limb, joint, and fluorescence/bioluminescence imaging. Although the spatial resolution is limited when compared with other imaging modalities, such as magnetic resonance imaging (MRI) or X-ray computerized tomography (CT), DOT provides access to a variety of physiological parameters that otherwise are not accessible, including sub-second imaging of hemodynamics and other fast-changing processes. Furthermore, DOT can be realized in compact, portable instrumentation that allows for bedside monitoring at relatively low cost. In this paper, we present an overview of current state-of-the -art technology, including hardware and image-reconstruction algorithms, and focus on applications in brain and joint imaging. In addition, we present recent results of work on optical tomographic imaging in small animals.
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