Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials.
Iridium oxide nanotube electrodes for sensitive and prolonged intracellular measurement of action potentials.
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DOI：
10.1038/ncomms4206
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发表时间：
2014
影响因子：
16.6
通讯作者：
Cui, Bianxiao
中科院分区：
文献类型：
--
作者：
Lin, Ziliang Carter;Xie, Chong;Osakada, Yasuko;Cui, Yi;Cui, Bianxiao
Intracellular recording of action potentials is important to understand electrically-excitable cells. Recently, vertical nanoelectrodes have been developed to achieve highly sensitive, minimally invasive, and large scale intracellular recording. It has been demonstrated that the vertical geometry is crucial for the enhanced signal detection. Here we develop nanoelectrodes made up of nanotubes of iridium oxide. When cardiomyocytes are cultured upon those nanotubes, the cell membrane not only wraps around the vertical tubes but also protrudes deep into the hollow center. We show that this geometry enhances cell-electrode coupling and results in measuring much larger intracellular action potentials. The nanotube electrodes afford much longer intracellular access and are minimally invasive, making it possible to achieve stable recording up to an hour in a single session and more than 8 days of consecutive daily recording. This study suggests that the electrode performance can be significantly improved by optimizing the electrode geometry.
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DOI：
10.1002/jbm.b.31223
发表时间：
2009-05
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Cogan SF;Ehrlich J;Plante TD;Smirnov A;Shire DB;Gingerich M;Rizzo JF
通讯作者：
Rizzo JF
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
3.5
作者：
Berthing, Trine;Bonde, Sara;Martinez, Karen L.
通讯作者：
Martinez, Karen L.
影响因子：
12.6
作者：
CONNOLLY, P;CLARK, P;WILKINSON, CDW
通讯作者：
WILKINSON, CDW
DOI：
10.1073/pnas.0909250107
发表时间：
2010-03-30
影响因子：
11.1
作者：
Almquist, Benjamin D.;Melosh, Nicholas A.
通讯作者：
Melosh, Nicholas A.