The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body (18)F-FDG PET/CT study.
The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body (18)F-FDG PET/CT study.
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类固醇糖尿病与 2 型糖尿病的区别：全身 18F-FDG PET/CT 研究
DOI：
10.1007/s00592-020-01566-w
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发表时间：
2020-11
影响因子：
3.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhao Q;Zhou J;Pan Y;Ju H;Zhu L;Liu Y;Zhang Y
目标
类固醇糖尿病(SDM)是一种糖皮质激素增多引起的代谢综合征，其发病机制尚不清楚。18F-FDGPET/CT能反映组织器官在生活条件下的糖代谢情况。本研究通过对SDM和2型糖尿病(T2 DM)大鼠的PET/CT显像，观察SDM大鼠主要糖代谢器官的糖代谢变化，探讨SDM的发病机制。
方法
建立SDM和T2 DM大鼠模型。在此期间，用PET/CT成像测量骨骼肌和肝脏的%ID/g值，以评估葡萄糖摄取。取胰腺、骨骼肌和肝脏进行免疫组织化学分析。
结果
SDM大鼠空腹血糖和胰岛素水平升高，胰岛α和β细胞增生，骨骼肌摄取FDG增加，PI3Kp85α、IRS-1和GLUT4表达上调，肝脏摄取无明显变化，肝脏和骨骼肌糖原储存量增加。T2 DM大鼠表现为胰岛β细胞萎缩，胰岛素水平降低，骨骼肌和肝脏摄取FDG和糖原储存显著减少。
结论
SDM的发病机制与T2 DM不同。骨骼肌糖代谢增加可能与胰岛素代偿分泌增加有关。糖皮质激素促进胰岛α细胞的增殖，并导致肝脏糖异生增加，这可能导致血糖升高。
Aims
Steroid diabetes mellitus (SDM) is a metabolic syndrome caused by an increase in glucocorticoids, and its pathogenesis is unclear. 18F-FDG PET/CT can reflect the glucose metabolism of tissues and organs under living conditions. Here, PET/CT imaging of SDM and type 2 diabetes mellitus (T2DM) rats was used to visualize changes in glucose metabolism in the main glucose metabolizing organs and investigate the pathogenesis of SDM.
Methods
SDM and T2DM rat models were established. During this time, PET/CT imaging was used to measure the %ID/g value of skeletal muscle and liver to evaluate glucose uptake. The pancreatic, skeletal muscle and liver were analyzed by immunohistochemistry.
Results
SDM rats showed increased fasting blood glucose and insulin levels, hyperplasia of islet α and β cells, increased FDG uptake in skeletal muscle accompanied by an up-regulation of PI3Kp85α, IRS-1, and GLUT4, no significant changes in liver uptake, and that glycogen storage in the liver and skeletal muscle increased. T2DM rats showed atrophy of pancreatic islet β cells and decreased insulin levels, significantly reduced FDG uptake and glycogen storage in skeletal muscle and liver.
Conclusions
The pathogenesis of SDM is different from that of T2DM. The increased glucose metabolism of skeletal muscle may be related to the increased compensatory secretion of insulin. Glucocorticoids promote the proliferation of islet α cells and cause an increase in gluconeogenesis in the liver, which may cause increased blood glucose.
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影响因子：
1.1
作者：
Martínez, Beatriz Bertolaccini;Pereira, Ana Carolina Couto;Teixeira, Manoel Araújo
通讯作者：
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影响因子：
3.1
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影响因子：
4
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
Cui, Anfang;Fan, Heng;Chang, Yongsheng
通讯作者：
Chang, Yongsheng