Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review.
Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review.
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DOI：
10.1039/c9cs00621d
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发表时间：
2022-01-04
影响因子：
46.2
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中科院分区：
文献类型：
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本文综述了可见光和近红外（NIR）荧光和表面增强拉曼散射（Sers）的概念、原理及其在体外床旁检测（POCT）和体内生物成像中的应用。讨论了如何利用生物透明窗提高穿透深度和信噪比，以及如何利用表面等离子体共振（SPR）放大荧光和Sers信号。本文重点介绍了一些等离子体荧光和Sers探针。综述了金属离子、小分子、蛋白质和核酸等的荧光和Sers传感器的设计策略。特别是，它提供了将荧光和Sers传感器集成到微流控芯片中作为芯片实验室以实现即时检测的前景。它还讨论了用于体外诊断的主动微流体装置和非纸基或纸基侧向流测定的设计。此外，本文还讨论了设计用于监测活细胞和组织中的生理过程和疾病进展的体内NIR荧光和Sers生物成像平台的策略。此外，它还强调了POCT和生物成像在检测毒素、重金属、非法药物、癌症、创伤性脑损伤、感染性疾病（如COVID-19、流感、艾滋病毒和败血症）方面的应用。本文综述了可见光、近红外荧光和表面增强拉曼散射技术的原理、设计及其在床旁检测和生物成像中的应用。
This review article deals with concepts, principles and applications of visible-light and near-infrared (NIR) fluorescence and surface-enhanced Raman scattering (SERS) in in vitro point-of-care testing (POCT) and in-vivo bio-imaging. It has discussed how to utilize the biological transparency windows to improve penetration depth and signal-to-noise ratio, and how to use surface plasmon resonance (SPR) to amplify fluorescence and SERS signals. This article has highlighted some plasmonic fluorescence and SERS probes. It has also reviewed the design strategies of fluorescent and SERS sensors in detection of metal ions, small molecules, proteins and nucleic acids. Especially, it has provided perspectives on integration of fluorescent and SERS sensors into microfluidic chips as lab-on-chips to realize point-of-care testing. It has also discussed the design of active microfluidic devices and non-paper- or paper-based lateral flow assays for in vitro diagnostics. In addition, this article has discussed the strategies to design in vivo NIR fluorescence and SERS bio-imaging platforms for monitoring physiological processes and disease progression in live cells and tissues. Moreover, it has highlighted applications of POCT and bio-imaging in testing toxins, heavy metals, illicit drugs, cancers, traumatic brain injury, infectious diseases such as COVID-19, influenza, HIV and sepsis. This article reviews the principles, design and applications of visible-light and near-infrared fluorescence and surface-enhanced Raman scattering in point-of-care testing and bio-imaging.
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