Combined robot motor assistance with neural circuit-based virtual reality (NeuCir-VR) lower extremity rehabilitation training in patients after stroke: a study protocol for a single-centre randomised controlled trial.
Combined robot motor assistance with neural circuit-based virtual reality (NeuCir-VR) lower extremity rehabilitation training in patients after stroke: a study protocol for a single-centre randomised controlled trial.
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机器人运动辅助与基于神经回路的虚拟现实 (NeuCir-VR) 下肢康复训练相结合，用于中风后患者：单中心随机对照试验的研究方案
DOI：
10.1136/bmjopen-2022-064926
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发表时间：
2022-12-23
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
改善下肢运动功能是脑卒中后康复治疗的重点和难点。最近，机器人辅助和虚拟现实（VR）训练通常用于中风后康复，并被认为是可行的治疗方法。在这里，我们开发了一种康复系统，将机器人运动辅助与基于神经回路的VR（NeuCir-VR）康复计划相结合，包括具有奖励机制的程序性下肢康复，从肌肉力量训练，姿势控制和平衡训练到简单和复杂的地面行走训练。本研究旨在探讨机器人运动辅助与NeuCir-VR下肢康复训练相结合在脑卒中患者中的有效性和神经机制。这是一项单中心、双盲、随机对照试验。将招募40例脑卒中后下肢轻偏瘫患者，按1：1的比例随机分为对照组（机器人辅助与VR训练联合）和干预组（机器人辅助与NeuCir-VR训练联合）。每个小组每周将接受5次30分钟的会议，为期4周。主要结局为下肢Fugl-Meyer评估。次要结局将包括贝格平衡量表、改良Ashworth量表和通过静息态功能MRI测量的功能连接。将在基线（T0）、干预后（T1）和随访（T2-T4）时测量结局。本试验已获得上海中医药大学岳阳中西医结合医院伦理委员会批准（批准号：2019 - 014）。研究结果将提交给同行评审期刊或会议。ChiCTR 2100052133。
Improving lower extremity motor function is the focus and difficulty of post-stroke rehabilitation treatment. More recently, robot-assisted and virtual reality (VR) training are commonly used in post-stroke rehabilitation and are considered feasible treatment methods. Here, we developed a rehabilitation system combining robot motor assistance with neural circuit-based VR (NeuCir-VR) rehabilitation programme involving procedural lower extremity rehabilitation with reward mechanisms, from muscle strength training, posture control and balance training to simple and complex ground walking training. The study aims to explore the effectiveness and neurological mechanisms of combining robot motor assistance and NeuCir-VR lower extremity rehabilitation training in patients after stroke. This is a single-centre, observer-blinded, randomised controlled trial. 40 patients with lower extremity hemiparesis after stroke will be recruited and randomly divided into a control group (combined robot assistance and VR training) and an intervention group (combined robot assistance and NeuCir-VR training) by the ratio of 1:1. Each group will receive five 30 min sessions per week for 4 weeks. The primary outcome will be Fugl-Meyer assessment of the lower extremity. Secondary outcomes will include Berg Balance Scale, Modified Ashworth Scale and functional connectivity measured by resting-state functional MRI. Outcomes will be measured at baseline (T0), post-intervention (T1) and follow-ups (T2–T4). The trial was approved by the Ethics Committee of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Chinese Traditional Medicine (Grant No. 2019–014). The results will be submitted to a peer-reviewed journal or at a conference. ChiCTR2100052133.
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DOI：
10.1016/s0003-9993(95)80038-7
发表时间：
1995-01-01
影响因子：
4.3
作者：
JORGENSEN, HS;NAKAYAMA, H;OLSEN, TS
通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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Mueller, Friedemann
丰富的环境通过促进自噬促进中风后神经功能的恢复
影响因子：
6.1
作者：
Deng YH;Dong LL;Zhang YJ;Zhao XM;He HY
通讯作者：
He HY