Epidemiology of Viruses Causing Pediatric Community Acquired Pneumonia in Shanghai During 2010-2020: What Happened Before and After the COVID-19 Outbreak?
Epidemiology of Viruses Causing Pediatric Community Acquired Pneumonia in Shanghai During 2010-2020: What Happened Before and After the COVID-19 Outbreak?
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DOI：
10.1007/s40121-021-00548-x
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发表时间：
2022-03
影响因子：
5.4
通讯作者：
Shen J
中科院分区：
文献类型：
--
作者：
Li F;Zhang Y;Shi P;Cao L;Su L;Zhang Y;Peng K;Lu R;Tan W;Shen J
自2019冠状病毒病全球爆发以来，儿科门诊和传染病急诊就诊人数大幅减少。本研究的目的是分析近10年来上海地区社区获得性肺炎（CAP）患儿呼吸道病毒的变化，特别是在COVID-19后的第一年。我们进行了一项回顾性观察性研究；对2010-2020年复旦大学儿童医院住院CAP病例的8种常见呼吸道病毒（呼吸道合胞病毒（RSV）、流感病毒A和流感病毒B、副流感病毒1-3 （PIV）、腺病毒（ADV）和人偏肺病毒）的直接荧光抗体检测结果进行分析。在本研究纳入的5544例CAP住院患者中，20.2%（1125/5544）的患者8种呼吸道病毒呈阳性。前3位分别为RSV、PIV3和ADV，检出率分别为9.8%（543/5544）、5.3%（294/5544）和2.0%（111/5544）。RSV阳性率在2岁以下儿童中最高。2020年2月至8月，所有病毒的检出率与前9年相比出现大幅下降。2020年8月上海社区重新开放，9月份8种病毒检出率明显回升。这8种呼吸道病毒，尤其是RSV和PIV，是近10年上海儿童CAP的重要病原体。新冠肺炎疫情对上海市CAP患儿8种呼吸道病毒检出率有显著影响。
Since the global outbreak of COVID-19, there has been a significant reduction in pediatric outpatient and emergency visits for infectious diseases. The purpose of this study was to analyze the changes in respiratory viruses in children with community-acquired pneumonia (CAP) in Shanghai in the past 10 years, especially in the first year after COVID-19. We conducted a retrospective, observational study; the results for eight common respiratory viruses (respiratory syncytial virus (RSV), influenza virus A and B, parainfluenza virus 1–3 (PIV), adenovirus (ADV) and human metapneumovirus) tested by direct fluorescent antibody assays in hospitalized CAP cases in Children’s Hospital of Fudan University during 2010–2020 were analyzed. Of the 5544 hospitalized CAP patients included in this study, 20.2% (1125/5544) were positive for the eight respiratory viruses. The top three pathogens were RSV, PIV3 and ADV, detected from 9.8% (543/5544), 5.3% (294/5544) and 2.0% (111/5544) of the samples, respectively. RSV had the highest positive rates among children < 2 years old. In 2020, the detection rate of all viruses showed a sharp decline from February to August compared with the previous 9 years. When the Shanghai community reopened in August 2020, the detection rate of eight viruses rebounded significantly in September. These eight respiratory viruses, especially RSV and PIV, were important pathogens of CAP in Shanghai children in the past 10 years. The COVID-19 pandemic had a significant impact on the detection rates for eight respiratory viruses in children with CAP in Shanghai.
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影响因子：
13.2
作者：
To KK;Sridhar S;Chiu KH;Hung DL;Li X;Hung IF;Tam AR;Chung TW;Chan JF;Zhang AJ;Cheng VC;Yuen KY
通讯作者：
Yuen KY
DOI：
10.1016/j.jinf.2020.11.010
发表时间：
2020-12
期刊：
The Journal of infection
影响因子：
--
作者：
Poole S;Brendish NJ;Clark TW
通讯作者：
Clark TW
影响因子：
5.2
作者：
Zhao, Yanjie;Shen, Jun;Tan, Wenjie
通讯作者：
Tan, Wenjie
DOI：
10.1016/j.jinf.2021.02.022
发表时间：
2021-04
期刊：
The Journal of infection
影响因子：
--
作者：
Mensah AA;Sinnathamby M;Zaidi A;Coughlan L;Simmons R;Ismail SA;Ramsay ME;Saliba V;Ladhani SN
通讯作者：
Ladhani SN
影响因子：
2.6
作者：
Li F;Wang Y;Zhang Y;Shi P;Cao L;Su L;Zhu Q;Wang L;Lu R;Tan W;Shen J
通讯作者：
Shen J