Effects of MK-801 on cerebral regional oxygen consumption in focal cerebral ischemia in rats.
Effects of MK-801 on cerebral regional oxygen consumption in focal cerebral ischemia in rats.
复制标题
MK-801 对局灶性脑缺血大鼠脑局部耗氧量的影响。
DOI：
10.1161/01.res.69.2.414
复制
发表时间：
1991
影响因子：
20.1
通讯作者：
Weiss,HR
中科院分区：
文献类型：
--
作者：
Chi,OZ;Anwar,M;Sinha,AK;Weiss,HR
本研究在大鼠中测试了MK-801（一种N-甲基-D-天冬氨酸受体拮抗剂）是否会改善大脑中动脉闭塞引起的脑局灶性缺血区的氧供应和消耗平衡。大脑中动脉闭塞后15 min，MK-801组（n = 12）静脉给予5 mg/kg MK-801，对照组（n = 12）给予生理盐水。每组闭塞后一小时，使用[14 C]碘安替比林测定六只大鼠的局部脑血流量，并使用显微分光光度技术测定其他六只大鼠的局部动脉和静脉血氧饱和度。在两组动物中，缺血皮质的脑血流量均显著低于对侧皮质（对照组分别为36 +/-16 [SD]和67 +/-14 ml/min/100 g; MK-801组分别为33 +/-10和58 +/-11 ml/min/100 g）。对于对照组，缺血皮质中的氧提取（8.8 +/-2.1 ml O2/100 ml血液）显著高于对侧皮质中的氧提取（5.6 +/-0.3）。然而，对于MK-801组，缺血皮质（6.1 +/-1.0）和对侧皮质（5.7 +/-1.1）之间无显著差异。MK-801组缺血皮质氧摄取量明显低于对照组。计算的缺血性局部耗氧量与对照组的非缺血性值相似，而MK-801组的缺血性值降低至对侧皮质值的61%。（250字处删节）
This investigation tested in rats whether MK-801, an N-methyl-D-aspartate receptor antagonist, would improve the balance of oxygen supply and consumption in the focal ischemic area of the brain induced by occlusion of the middle cerebral artery. Fifteen minutes after middle cerebral artery occlusion, 5 mg/kg MK-801 was administered intravenously to the MK-801 group (n = 12), and normal saline was given to the control group (n = 12). One hour after the occlusion in each group, regional cerebral blood flow was determined in six rats using [14C]iodoantipyrine, and regional arterial and venous oxygen saturations were determined using a microspectrophotometric technique in the other six rats. In both groups of animals, the cerebral blood flow of the ischemic cortex was significantly lower than that of the contralateral cortex (36 +/- 16 [SD] and 67 +/- 14 ml/min/100 g for the control group; 33 +/- 10 and 58 +/- 11 ml/min/100 g for the MK-801 group, respectively). Oxygen extraction was significantly higher in the ischemic cortex (8.8 +/- 2.1 ml O2/100 ml blood) than in the contralateral cortex (5.6 +/- 0.3) for the control group. However, for the MK-801 group, there was no significant difference between the ischemic cortex (6.1 +/- 1.0) and the contralateral cortex (5.7 +/- 1.1). Oxygen extraction in the ischemic cortex of the MK-801 group was significantly lower than that of the control group. Calculated ischemic regional oxygen consumption was similar to the nonischemic values in the control group, whereas the ischemic value was reduced to 61% of the value of the contralateral cortex in the MK-801 group.(ABSTRACT TRUNCATED AT 250 WORDS)
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