Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.
Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.
复制标题
DOI：
10.4269/ajtmh.22-0530
复制
发表时间：
2023-08-02
期刊：
影响因子：
--
通讯作者：
Castillo-Neyra R
中科院分区：
文献类型：
--
作者：
Chuquista-Alcarraz O;Falcón N;Vigilato MAN;Rocha F;Toledo-Barone G;Amorim-Conselheiro J;Recuenco SE;Castillo-Neyra R
秘鲁的利马自1999年以来就没有出现过犬类狂犬病病例。然而，由于附近狂犬病流行地区的狗的自由流动，利马仍然存在狂犬病重新传入的风险。在拉丁美洲，狂犬病疫苗接种运动必须覆盖80%的犬只，才能阻止传播，但对疫苗覆盖率的估计往往无法获得、不可靠或不准确。定量病毒中和抗体（VNA）可以监测犬群的免疫状态，评估对病毒的体液保护程度，并部分评估犬群对疫苗接种的反应。在利马开展大规模疫苗接种运动之前，我们评估了犬群对狂犬病毒的免疫水平。在苏基洛地区采集了141份犬血样本，采用荧光抗体病毒中和试验定量狂犬病病毒中和抗体滴度。我们调查了狗的主人，以重建犬的疫苗接种史。在先前接种过疫苗的狗中，73.9%超过了血清转化阈值>.5 IU/mL。在所有犬中，只有58.2%达到血清转化滴度限值。1岁以下犬只占总犬只的26.2%，其VNA水平低于1岁以下犬只（χ2 = 9.071; P = 0.028）。重要的是，接种单一病原体疫苗的狗的VNA水平高于接种联合病原体疫苗的狗（χ2 = 7.721; P = 0.005）。我们为利马市区犬群免疫状况提供了重要和及时的一瞥，利马是一个靠近犬狂犬病流行区的大都市。
Lima, Peru, has not had a case of canine rabies since 1999. However, Lima remains at risk of rabies reintroduction due to the free movement of dogs from nearby rabies-endemic areas. In Latin America, rabies vaccination campaigns must reach 80% of dogs to halt transmission, but estimates of vaccine coverage are often unavailable, unreliable, or inaccurate. Quantifying virus neutralizing antibodies (VNA) allows monitoring of the immunological status of the canine population, evaluation of the degree of humoral protection to the virus, and assessing, partially, the population response to vaccination. We evaluated the dog population’s immunity level against the rabies virus before a mass vaccination campaign in Lima. We collected 141 canine blood samples in the district of Surquillo and quantified rabies virus neutralizing antibody titers using the fluorescent antibody virus neutralization test). We surveyed dogs owners to reconstruct canine vaccination histories. Among dogs previously vaccinated, 73.9% exceeded the seroconversion threshold of > 0.5 IU/mL. Among all dogs, only 58.2% reached the titer limit for seroconversion. Dogs ≤ 1 year old constituted 26.2% of the total canine population and had lower levels of VNA than dogs > 1 year old (χ2 = 9.071; P = 0.028). Importantly, dogs vaccinated with single-pathogen vaccines had higher levels of VNA than those who received combined-pathogen vaccines (χ2 = 7.721; P = 0.005). We provide an important and timely glimpse to the immunity status of the dog population in urban areas of Lima, a metropolis near a dog rabies–endemic region.
登录
查看更多内容
影响因子：
5.5
作者：
Kennedy, Lorna J.;Lunt, Mark;Ollier, William E. R.
通讯作者：
Ollier, William E. R.
影响因子：
3.8
作者：
Gnanadurai CW;Yang Y;Huang Y;Li Z;Leyson CM;Cooper TL;Platt SR;Harvey SB;Hooper DC;Faber M;Fu ZF
通讯作者：
Fu ZF
影响因子：
2.9
作者：
Castillo-Neyra, Ricardo;Zegarra, Edith;Levy, Michael Z.
通讯作者：
Levy, Michael Z.
DOI：
10.1186/1678-9199-20-37
发表时间：
2014-01-01
影响因子：
2.4
作者：
Babboni, Selene Daniela;Costa, Hení Falcão da;Modolo, José Rafael
通讯作者：
Modolo, José Rafael
影响因子：
7.8
作者：
Leelahapongsathon K;Kasemsuwan S;Pinyopummintr T;Boodde O;Phawaphutayanchai P;Aiyara N;Bobe K;Vos A;Friedrichs V;Müller T;Freuling CM;Chanachai K
通讯作者：
Chanachai K