A POROELASTIC MODEL FOR CELL CRAWLING INCLUDING MECHANICAL COUPLING BETWEEN CYTOSKELETAL CONTRACTION AND ACTIN POLYMERIZATION.
A POROELASTIC MODEL FOR CELL CRAWLING INCLUDING MECHANICAL COUPLING BETWEEN CYTOSKELETAL CONTRACTION AND ACTIN POLYMERIZATION.
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DOI：
10.2140/jomms.2011.6.569
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发表时间：
2011
影响因子：
0.9
通讯作者：
Bayly PV
中科院分区：
文献类型：
--
作者：
Taber LA;Shi Y;Yang L;Bayly PV
人们对细胞爬行的生物物理机制了解很多，但如何协调这些过程以产生定向运动尚不清楚。在这里，我们提出了一个新的假设，即局部细胞骨架收缩产生通过片状足的流体流，细胞前部的压力促进肌动蛋白聚合，从而推动前缘向前。反过来，收缩又受到细胞骨架压力的调节。为了检验这一假设，提出了爬行单元的有限元模型。这些模型基于非线性孔隙弹性理论，经过修改以包括主动收缩和增长的影响，这些影响由机械反馈定律调节。该模型的结果与已发表的关于迁移鱼表皮角膜细胞的细胞速度、肌动蛋白流量和细胞骨架变形的实验数据相当吻合。该模型还表明，在某些参数值范围内可能会发生振荡。
Much is known about the biophysical mechanisms involved in cell crawling, but how these processes are coordinated to produce directed motion is not well understood. Here, we propose a new hypothesis whereby local cytoskeletal contraction generates fluid flow through the lamellipodium, with the pressure at the front of the cell facilitating actin polymerization which pushes the leading edge forward. The contraction, in turn, is regulated by stress in the cytoskeleton. To test this hypothesis, finite element models for a crawling cell are presented. These models are based on nonlinear poroelasticity theory, modified to include the effects of active contraction and growth, which are regulated by mechanical feedback laws. Results from the models agree reasonably well with published experimental data for cell speed, actin flow, and cytoskeletal deformation in migrating fish epidermal keratocytes. The models also suggest that oscillations can occur for certain ranges of parameter values.
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影响因子：
2.6
作者：
Flaherty, Brendan;McGarry, J. P.;McHugh, P. E.
通讯作者：
McHugh, P. E.
DOI：
10.1513/pats.200705-056vs
发表时间：
2008-01-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Bosse, Ynuk;Sobieszek, Apolinary;Seow, Chun Y
通讯作者：
Seow, Chun Y
影响因子：
64.8
作者：
Keren, Kinneret;Pincus, Zachary;Theriot, Julie A.
通讯作者：
Theriot, Julie A.
影响因子：
1.9
作者：
Kuusela, Esa;Alt, Wolfgang
通讯作者：
Alt, Wolfgang
影响因子：
3.4
作者：
Barnhart, Erin L.;Allen, Greg M.;Theriot, Julie A.
通讯作者：
Theriot, Julie A.