Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.
Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.
复制标题
作者：
在这篇综述中，我们将讨论通过生物聚合物支架递送细胞外囊泡（EV）用于治疗应用的现状以及与这些功能化支架的开发相关的挑战。 EV 是细胞衍生的膜结构，参与许多生理过程。原始和工程化的 EV 具有很大的治疗潜力，但需要适当的输送系统来防止非特异性和脱靶效应。使用聚合物支架进行靶向和位点特异性递送可以解决这些限制。使用支架进行 EV 输送已显示出在组织重塑、伤口愈合、骨愈合、免疫调节和血管性能方面的改善。因此，通过生物聚合物支架进行 EV 递送正在成为一种越来越流行的组织工程方法。尽管天然和合成生物聚合物有多种类型，但许多组织工程师的首要目标是利用生物聚合物来恢复缺陷和功能以及支持宿主再生。通过结合电动汽车来功能化生物聚合物可以实现这一目标。在整个综述中，我们将描述细胞外囊泡的特征，研究作为治疗目的的 EV 递送载体的各种生物聚合物、EV 发挥其作用的潜在机制、用于组织修复和免疫调节的 EV 递送，以及与在支架中使用 EV 相关的挑战。
In this review, we will discuss the current status of extracellular vesicle (EV) delivery via biopolymeric scaffolds for therapeutic applications and the challenges associated with the development of these functionalized scaffolds. EVs are cell-derived membranous structures and are involved in many physiological processes. Naïve and engineered EVs have much therapeutic potential, but proper delivery systems are required to prevent non-specific and off-target effects. Targeted and site-specific delivery using polymeric scaffolds can address these limitations. EV delivery with scaffolds has shown improvements in tissue remodeling, wound healing, bone healing, immunomodulation, and vascular performance. Thus, EV delivery via biopolymeric scaffolds is becoming an increasingly popular approach to tissue engineering. Although there are many types of natural and synthetic biopolymers, the overarching goal for many tissue engineers is to utilize biopolymers to restore defects and function as well as support host regeneration. Functionalizing biopolymers by incorporating EVs works toward this goal. Throughout this review, we will characterize extracellular vesicles, examine various biopolymers as a vehicle for EV delivery for therapeutic purposes, potential mechanisms by which EVs exert their effects, EV delivery for tissue repair and immunomodulation, and the challenges associated with the use of EVs in scaffolds.
登录
查看更多内容
影响因子：
2.7
作者：
Bai, Yan;Moeinzadeh, Seyedsina;Yang, Yunzhi Peter
通讯作者：
Yang, Yunzhi Peter
影响因子：
4.6
作者：
Brennan, K.;Martin, K.;Mc Gee, M. M.
通讯作者：
Mc Gee, M. M.
影响因子：
4.6
作者：
Alallam, Batoul;Altahhan, Sara;Doolaanea, Abd Almonem
通讯作者：
Doolaanea, Abd Almonem
双壁多壁聚（D，L-丙二醇 - 糖糖苷）（PLGA）和聚（L-甲状腺素）（PLLA）纳米颗粒，用于持续释放阿霉素。
影响因子：
5
作者：
Cardoso MM;Peca IN;Lopes T;Gardner R;Bicho A
通讯作者：
Bicho A
影响因子：
8
作者：
Akiyama N;Yamamoto-Fukuda T;Takahashi H;Koji T
通讯作者：
Koji T