Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza.
Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza.
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仿生抗原纳米颗粒引起对流感的保护性免疫反应。
DOI：
10.1021/nn4006544
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发表时间：
2013-04-23
期刊：
影响因子：
17.1
通讯作者：
Douglas, Trevor
中科院分区：
文献类型：
--
作者：
Patterson, Dustin P.;Rynda-Apple, Agnieszka;Harmsen, Ann L.;Harmsen, Allen G.;Douglas, Trevor
Here we present a biomimetic strategy towards nanoparticle design for controlled immune response through encapsulation of conserved internal influenza proteins on the interior of virus like particles (VLPs) to direct CD8+ cytotoxic T cell protection. Programmed encapsulation and sequestration of the conserved nucleoprotein (NP) from influenza on the interior of a VLP, derived from the bacteriophage P22, results in a vaccine that provides multi-strain protection against 100 times lethal doses of influenza in an NP specific CD8+ T cell-dependent manner. VLP assembly and encapsulation of the immunogenic NP cargo protein is the result of a genetically programmed self-assembly making this strategy amendable to the quick production of vaccines to rapidly emerging pathogens. Addition of adjuvants or targeting molecules were not required for eliciting the protective response.
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Kawaoka, Yoshihiro
DOI：
10.1126/science.1213362
发表时间：
2012-06-22
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Herfst S;Schrauwen EJ;Linster M;Chutinimitkul S;de Wit E;Munster VJ;Sorrell EM;Bestebroer TM;Burke DF;Smith DJ;Rimmelzwaan GF;Osterhaus AD;Fouchier RA
通讯作者：
Fouchier RA