The alien limb phenomenon.
The alien limb phenomenon.
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DOI：
10.1007/s00415-013-6898-y
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发表时间：
2013-07
影响因子：
6
通讯作者：
Josephs KA
中科院分区：
文献类型：
--
作者：
Graff-Radford J;Rubin MN;Jones DT;Aksamit AJ;Ahlskog JE;Knopman DS;Petersen RC;Boeve BF;Josephs KA
异肢现象是指肢体的无意识运动活动，并伴有与该肢体疏远的感觉。异肢可作为皮质基底动脉综合征的诊断特征。我们的目的是确定异肢的鉴别诊断，并确定一大群具有不同潜在病因的异肢患者的特征。我们检索了马约诊所医疗记录链接系统，以确定1996年1月1日至2011年7月11日期间诊断为异肢的患者。150例异肢患者被确定。22人在阿尔茨海默病研究中心接受了随访。异肢的病因包括皮质基底综合征（n=108）、卒中（n=14）、克雅氏病（n=9）、遗传性弥漫性白质脑病伴球状体（n=5）、肿瘤（n=4）、进行性多灶性白质脑病（n=2）、脱髓鞘病（n = 2）、进行性痴呆（n = 2）、可逆性后部脑病综合征（n=1）、胼胝体切开术（n=1）、脑出血（n=1）和丘脑痴呆（n=1）。14例脑血管病中10例起源于右半球。所有病例均累及顶叶。来自阿尔茨海默病研究中心队列的44例皮质基底动脉综合征患者中，22例有异肢，73%的异肢累及左侧肢体。左侧皮质基底动脉综合征与异肢的存在显著相关（p=0.004）。这些发现支持了这样一种观点，即异肢现象部分与顶叶皮层（尤其是右顶叶）的损伤有关，使其与其他皮层区域断开。
Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb. Alien limb serves as a diagnostic feature of corticobasal syndrome. Our objective was to determine the differential diagnoses of alien limb and to determine the features in a large group of patients with the alien limb with different underlying etiologies. We searched the Mayo Clinic Medical Records Linkage system to identify patients with the diagnosis of alien limb seen between January 1, 1996, and July 11, 2011. One hundred fifty patients with alien limb were identified. Twenty two were followed in the Alzheimer’s Disease Research Center. Etiologies of alien limb included corticobasal syndrome (n=108), stroke (n=14), Creutzfeldt Jacob disease (n=9), Hereditary diffuse leukoencephalopathy with spheroids (n=5), tumor (n=4), progressive multifocal leukoencephalopathy(n=2), demyelinating disease (n=2), progressive dementia not otherwise specified (n=2), posterior reversible encephalopathy syndrome (n=1), corpus callosotomy (n=1), intracerebral hemorrhage (n=1) and thalamic dementia (n=1). Ten of fourteen cerebrovascular cases were right hemisphere in origin. All cases involved the parietal lobe. Of the 44 patients with corticobasal syndrome from the Alzheimer’s Disease Research Center cohort, 22 had alien limb, and 73% had the alien limb affecting the left extremities. Left sided corticobasal syndrome was significantly associated with the presence of alien limb (p=0.004). These findings support the notion that the alien limb phenomenon is partially related to damage underlying the parietal cortex, especially the right parietal, disconnecting it from other cortical areas.
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影响因子：
11
作者：
DOODY, RS;JANKOVIC, J
通讯作者：
JANKOVIC, J
影响因子：
9.9
作者：
GESCHWIND, DH;IACOBONI, M;ZAIDEL, E
通讯作者：
ZAIDEL, E
影响因子：
0.8
作者：
Kloesel, Benjamin;Czarnecki, Kathrin;Keller, A. Scott
通讯作者：
Keller, A. Scott
影响因子：
--
作者：
Kompoliti, K;Goetz, CG;Riley, DE
通讯作者：
Riley, DE
影响因子：
9.9
作者：
Boeve, BF;Maraganore, DM;Petersen, RC
通讯作者：
Petersen, RC