Endocannabinoids and endovanilloids: a possible balance in the regulation of the testicular GnRH signalling.

Endocannabinoids and endovanilloids: a possible balance in the regulation of the testicular GnRH signalling.
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DOI:
10.1155/2013/904748
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发表时间:
2013
影响因子:
2.8
通讯作者:
Meccariello R
Meccariello R
中科院分区:
医学4区
文献类型:
--
作者:
Chianese R;Ciaramella V;Scarpa D;Fasano S;Pierantoni R;Meccariello R

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生殖功能在中枢(脑)和性腺两个层面上都受到调节。在这方面,内源性大麻素系统(eCS)具有非常重要的作用。有趣的是,eCS的表征从使用不同于哺乳动物的动物模型中获得了许多优势。因此,本文综述了无尾两栖动物蛙(Rana esculenta)eCS的主要证据,特别是eCS与促性腺激素释放激素(GnRH)之间的形态功能关系。此外,一个新的作用,内源性香草素在睾丸GnRH系统的调节也将进行讨论。
Reproductive functions are regulated both at central (brain) and gonadal levels. In this respect, the endocannabinoid system (eCS) has a very influential role. Interestingly, the characterization of eCS has taken many advantages from the usage of animal models different from mammals. Therefore, this review is oriented to summarize the main pieces of evidence regarding eCS coming from the anuran amphibian Rana esculenta, with particular interest to the morphofunctional relationship between eCS and gonadotropin releasing hormone (GnRH). Furthermore, a novel role for endovanilloids in the regulation of a testicular GnRH system will be also discussed.
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